Inhibition of putrescine synthesis blocks development of the polychete Ophryotrocha labronica at gastrulation.
Inhibition of putrescine synthesis blocks development of the polychete Ophryotrocha labronica at gastrulation.
复制标题
抑制腐胺合成可阻止多壳动物 Ophryotrocha labronica 在原肠胚形成时的发育。
DOI：
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发表时间：
1978
影响因子：
11.1
通讯作者：
O. Heby
中科院分区：
文献类型：
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作者：
H. Emanuelsson;O. Heby
在受精后的第一个6天内，对多毛类Ophryotrocha labronica的发育卵进行了多胺分析。精胺含量起初占优势，但逐渐下降。腐胺超过了它，在第3天迅速增加到最大值，即，在格律形成的初期。亚精胺含量在整个时期都很低。从发育开始用腐胺合成抑制剂α-甲基鸟氨酸处理鸡蛋导致原肠胚形成时发育停滞，并且处理的胚胎中腐胺含量异常低。精胺和亚精胺合成的抑制剂甲基乙二醛双（鸟苷酰腙）对发育没有明显影响。我们的观察强烈表明腐胺的合成是必不可少的早期胚胎发育的Ophryotrocha。
Development eggs of the polychete Ophryotrocha labronica were analyzed for polyamines during the first 6 days after fertilization. The spermine content dominated initially, but gradually decreased. It was surpassed by putrescine, which rapidly increased to a maximum on the 3rd day, i.e., at the inception of grastrulation. The spermidine content was low during the entire period. Treatment of eggs with the putrescine synthesis inhibitor alpha-methylornithine from the onset of development led to developmental arrest at gastrulation and to an abnormally low content of putrescine in the treated embryos. Methylglyoxal bis(guanylhydrazone), an inhibitor of spermine and spermidine synthesis, had no visible effect of development. Our observations strongly suggest that putrescine synthesis is indispensable in early embryonic development of Ophryotrocha.