Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation.
Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation.
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DOI：
10.1364/boe.9.003122
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发表时间：
2018-07-01
影响因子：
3.4
通讯作者：
Munro PRT
中科院分区：
文献类型：
--
作者：
Ossowski P;Curatolo A;Sampson DD;Munro PRT
基于麦克斯韦方程组的光学相干层析成像成像的真实模拟，最近已被证明为具有实际意义的样品量。然而，仍然存在一个限制，即减少用于构建计算网格的单元的大小，从而允许散射体微观结构的更真实的表示，必然减少可以建模的总样本大小。这是一个重要的问题，因为众所周知，散射体的微结构显著影响其散射特性。在这里，我们证明了优化的散射体设计可以克服这个问题，从而在模拟和实验图像之间的结构化幻影良好的协议。OCT图像模拟的这种方法允许以前所未有的真实感模拟生物组织的图像形成。
Realistic simulation of image formation in optical coherence tomography, based on Maxwell’s equations, has recently been demonstrated for sample volumes of practical significance. Yet, there remains a limitation whereby reducing the size of cells used to construct a computational grid, thus allowing for a more realistic representation of scatterer microstructure, necessarily reduces the overall sample size that can be modelled. This is a significant problem since, as is well known, the microstructure of a scatterer significantly influences its scattering properties. Here we demonstrate that an optimized scatterer design can overcome this problem resulting in good agreement between simulated and experimental images for a structured phantom. This approach to OCT image simulation allows for image formation for biological tissues to be simulated with unprecedented realism.