Tissue repair and stem cell renewal in carcinogenesis
Tissue repair and stem cell renewal in carcinogenesis
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DOI：
10.1038/nature03100
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发表时间：
2004-11-18
期刊：
影响因子：
64.8
通讯作者：
Berman, DM
中科院分区：
文献类型：
--
作者：
Beachy, PA;Karhadkar, SS;Berman, DM
癌症越来越被视为一种干细胞疾病，因为它是由少数具有干细胞样特性的细胞繁殖的，也因为它可能来源于正常组织干细胞。但干细胞的活动受到严格控制，这就提出了一个问题，即正常的调控在癌变过程中是如何被破坏的。众所周知，癌症和慢性组织损伤之间的关联，以及最近对Hedgehog和Wnt信号通路在组织再生、干细胞更新和癌症生长中的作用的认识表明，癌变是通过滥用控制组织修复和干细胞自我更新的稳态机制来进行的。
Cancer is increasingly being viewed as a stem cell disease, both in its propagation by a minority of cells with stem-cell-like properties and in its possible derivation from normal tissue stem cells. But stem cell activity is tightly controlled, raising the question of how normal regulation might be subverted in carcinogenesis. The long-known association between cancer and chronic tissue injury, and the more recently appreciated roles of Hedgehog and Wnt signalling pathways in tissue regeneration, stem cell renewal and cancer growth together suggest that carcinogenesis proceeds by misappropriating homeostatic mechanisms that govern tissue repair and stem cell self-renewal.