Exploring Disease through Metabolomics
Exploring Disease through Metabolomics
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DOI：
10.1021/cb900271r
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发表时间：
2010-01-01
影响因子：
4
通讯作者：
Saghatelian, Alan
中科院分区：
文献类型：
--
作者：
Vinayavekhin, Nawaporn;Homan, Edwin A.;Saghatelian, Alan
代谢组学方法提供了对生物样品中变化的代谢物水平的分析。在过去的十年中，技术的进步促进了代谢组学在基础科学、生物医学和临床科学等不同研究领域的应用。特别是，仪器、数据分析软件的改进和代谢物数据库的发展加速了代谢物的测量和鉴定。代谢组学方法已被应用于许多重要问题，其中包括生物标志物的发现以及旨在发现调节细胞和生理过程的代谢物或代谢途径的机制研究。通过提供其他分析方法（如蛋白质组学和基因组学）未覆盖的部分生物分子空间，代谢组学为生物学中的小分子调控和信号传导提供了独特的见解。在下面的回顾中，我们将代谢组学方法整合到基础和生物医学研究的不同领域，并试图指出这些方法丰富了我们对细胞和生理生物学的理解的领域，特别是在与疾病相关的途径的背景下。
Metabolomics approaches provide an analysis of changing metabolite levels in biological samples. in the past decade, technical advances have spurred the application of metabolomics in a variety of diverse research areas spanning basic, biomedical, and clinical sciences. In particular, improvements in instrumentation, data analysis software, and the development of metabolite data-bases have accelerated the measurement and identification of metabolites. Metabolomics approaches have been applied to a number of important problems, which include the discovery of biomarkers as well as mechanistic studies aimed at discovering metabolites or metabolic pathways that regulate cellular and physiological processes. By providing access to a portion of biomolecular space not covered by other profiling approaches (e.g., proteomics, and genomics), metabolomics offers unique insights into small molecule regulation and signaling in biology. In the following review, we took at the integration of metabolomics approaches in different areas of basic and biomedical research, and try to point out the areas in which these approaches have enriched our understanding of cellular and physiological biology, especially within the context of pathways linked to disease.