Genetic predisposition to anxiety-related behavior predicts predator odor response
Genetic predisposition to anxiety-related behavior predicts predator odor response
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DOI：
10.1016/j.bbr.2011.07.022
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发表时间：
2011-11-20
影响因子：
2.7
通讯作者：
Landgraf, R.
中科院分区：
文献类型：
--
作者：
Sotnikov, S. V.;Markt, P. O.;Landgraf, R.
虽然啮齿类动物有敏锐的嗅觉，并且在很大程度上依赖嗅觉线索在其环境中运作，但大多数广泛使用的评估焦虑相关行为的测试在很大程度上忽略了嗅觉系统，主要基于对明亮灯光，新颖和开放空间的恐惧。在这里，我们的目的是测试是否遗传易感性焦虑预测捕食气味反应的小鼠。在第一个实验中，使用CD-1小鼠的3室回避试验，三甲基噻唑啉（TMT），一种合成的狐狸粪便气味，显示出诱导更强的行为和神经内分泌效应，分别比猫气味和丁酸，因此被选为厌恶的气味为以下一系列的实验。在这个系列中，双向，选择性近亲繁殖的CD-1小鼠与高（HAB），中间（NAB）或低（LAB）焦虑相关的行为作出不同的反应TMT，与HAB花费显着更少的时间比NAB和LAB在室内窝藏的捕食者气味。重要的是，该结果不受嗅觉系统的任何缺陷的混淆，因为LAB和NAB小鼠虽然对TMT没有或仅中度响应，但对女性尿液的令人愉快的气味和丁酸的令人厌恶的气味都有响应。可能是由于TMT的强度，在所有三个组中观察到捕食者气味暴露后皮质酮水平的类似增加。总之，这些结果表明，依赖于焦虑相关行为极端的遗传倾向，小鼠对潜在捕食者的气味有不同的解释，使得这种类型的回避行为高度可预测。(C)2011爱思唯尔有限公司版权所有。
While rodents have a keen sense of smell and largely depend on olfactory cues for operating in their environment, most of the widely used tests to assess anxiety-related behavior largely ignore the olfactory system, being primarily based on fear of brightly lit, novel and open spaces. Here, we aimed at testing whether the genetic predisposition to anxiety predicts the predator odor response in mice. In the first experiment, using the 3-chamber avoidance test in CD-1 mice, trimethylthiazoline (TMT), a synthetic fox fecal odor, was shown to induce stronger behavioral and neuroendocrine effects than cat odor and butyric acid, respectively, and was therefore chosen as aversive odor for the following series of experiments. In this series, bidirectionally, selectively inbred CD-1 mice with either high (HAB), intermediate (NAB) or low (LAB) anxiety-related behavior responded differently to TMT, with HABs spending significantly less time than both NABs and LABs in the chamber harbouring the predator odor. Importantly, this result is not confounded by any deficit of the olfactory system, as LAB and NAB mice, while not or only moderately responding to TMT, responded to both the pleasant odor of female urine and the repugnant odor of butyric acid. Probably due to the strength of TMT, a similar increase in corticosterone levels upon predator odor exposure was observed in all three groups. Together, the results suggest that, dependent on the genetic predisposition to extremes in anxiety-related behavior, mice differentially interpret the odor of a potential predator, making this type of avoidance behavior highly predictable. (C) 2011 Elsevier B.V. All rights reserved.