Gender differences in the response of plasma leptin concentrations to weight loss in obese older individuals
Gender differences in the response of plasma leptin concentrations to weight loss in obese older individuals
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DOI：
10.1002/j.1550-8528.1997.tb00284.x
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发表时间：
1997-01-01
期刊：
影响因子：
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通讯作者：
Goldberg, AP
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文献类型：
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作者：
Nicklas, BJ;Katzel, LI;Goldberg, AP
血浆瘦素浓度与肥胖程度直接相关，在相同的体重指数（BMI）下，女性的瘦素浓度高于男性。我们假设，空腹血浆瘦素浓度和瘦素对体重减轻的反应在脂肪量相似的老年男性和女性中会有所不同。血浆瘦素浓度（放射免疫分析）和脂肪量（DXA）仅测量47名老年肥胖者，（BMI=30 +/- 4 kg/m2）女性和23名老年肥胖者（BMI=31 +/- 3 kg/m2）的男性，在体重和饮食稳定2 - 4周后，然后在22名女性和18名男性中进行6个月的减肥干预（250-350千卡/天的赤字）。瘦素与男性和女性的脂肪量相关（分别为r=0.75和r=0.77; p值
Plasma leptin concentration is directly related to the degree of obesity and is higher in women than in men of the same body mass index (BMI). We hypothesized that fasting plasma leptin concentrations and the response of leptin to weight loss would differ in older men and women of a similar fat mass. Plasma leptin concentrations (radioimmunoassay) and fat mass (DXA) mere measured in 47 older, obese (BMI=30 +/- 4 kg/m(2)) women and 23 older, obese (BMI=31 +/- 3 kg/m(2)) men after a 2 to 4 week period of weight and dietary stabilization, and then in 22 of the women and 18 of the men after a 6-month weight loss intervention (250-350 kcal/d deficit). Leptin correlated with fat mass in men and women (r=0.75 and r=0.77, respectively; p values