Diffusion tensor imaging depicting damage to the arcuate fasciculus in patients with conduction aphasia: a study of the Wernicke–Geschwind model
Diffusion tensor imaging depicting damage to the arcuate fasciculus in patients with conduction aphasia: a study of the Wernicke–Geschwind model
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弥散张量成像描绘传导性失语症患者弓状束损伤：Wernicke-Geschwind 模型的研究
DOI：
10.1179/016164109x12478302362653
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发表时间：
2010-09
影响因子：
1.9
通讯作者：
Wang, Yongjun
中科院分区：
文献类型：
--
作者：
Zhao, Xingquan;Chen, Hongyan;Han, Zaizhu;Zhang, Yumei;Wang, Chunxue;Wang, Yongjun
摘要目标：与理解和自发表达障碍相反，传导性失语症的特征是重复性差，这是该综合征的标志。关于传导性失语的重复障碍有多种学说。切断学说认为，连接Broca区和Wernicke区的弓状束的损伤是传导性失语的原因。在这项研究中，我们研究了断开理论。研究方法：我们招募了10名传导性失语症患者和10名志愿者，使用扩散张量成像（DTI）分析他们的弓状神经束，并获得各向异性分数（FA）值。然后，将左右半球的结果进行比较，并将传导性失语病例的结果与志愿者的结果进行比较。结果：正常人与传导病例左右半球FA值差异有统计学意义。在志愿者中，左半球的纤维比右半球增加，而传导性失语症患者的右半球纤维比左半球增加。弥散张量纤维束成像结果显示，传导性失语患者弓状束形态与正常人不同，提示传导性失语患者弓状束存在损伤。结论：传导性失语患者弓状束的损害支持Wernicke-Geschwind断线学说。Broca区和Wernicke区的分离可能是传导性失语重复障碍的机制之一。
Abstract Objectives: In contrast with disorders of comprehension and spontaneous expression, conduction aphasia is characterized by poor repetition, which is a hallmark of the syndrome. There are many theories on the repetition impairment of conduction aphasia. The disconnection theory suggests that a damaged in the arcuate fasciculus, which connects Broca's and Wernicke's area, is the cause of conduction aphasia. In this study, we examined the disconnection theory. Methods: We enrolled ten individuals with conduction aphasia and ten volunteers, and analysed their arcuate fasciculus using diffusion tensor imaging (DTI) and obtained fractional anisotropy (FA) values. Then, the results of the left hemisphere were compared with those of the right hemisphere, and the results of the conduction aphasia cases were compared with those of the volunteers. Results: There were significant differences in the FA values between the left and right hemispheres of volunteers and conduction cases. In volunteers, there was an increase in fiber in the left hemisphere compared with the right hemisphere, whereas there was an increase in fiber in the right hemisphere compared with the left hemisphere in conduction aphasia patients. The results of diffusion tensor tractography suggested that the configuration of the arcuate fasciculus was different between conduction aphasia patients and volunteers, suggesting that there was damage to the arcuate fasciculus of conduction aphasia cases. Conclusions: The damage seen in the arcuate fasciculus of conduction aphasia cases in this study supports the Wernicke–Geschwind disconnection theory. A disconnection between Broca's area and Wernicke's area is likely to be one mechanism of conduction aphasia repetition impairment.
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影响因子：
2.8
作者：
M. Z. Hussain;M. Aihara;H. Oba;K. Ohtomo;G. Uchiyama;H. Hayashibe;S. Nakazawa
通讯作者：
M. Z. Hussain;M. Aihara;H. Oba;K. Ohtomo;G. Uchiyama;H. Hayashibe;S. Nakazawa
影响因子：
9.9
作者：
K. Yamada;Y. Nagakane;T. Mizuno;A. Hosomi;M. Nakagawa;T. Nishimura
通讯作者：
K. Yamada;Y. Nagakane;T. Mizuno;A. Hosomi;M. Nakagawa;T. Nishimura
影响因子：
3.6
作者：
G. Demeurisse;A. Capon
通讯作者：
G. Demeurisse;A. Capon
影响因子：
9.9
作者：
P. Arnett;S. Rao;M. Hussain;S. Swanson;T. Hammeke
通讯作者：
P. Arnett;S. Rao;M. Hussain;S. Swanson;T. Hammeke
DOI：
--
发表时间：
2002-08
期刊：
Rinsho shinkeigaku = Clinical neurology
影响因子：
--
作者：
K. Ibayashi
通讯作者：
K. Ibayashi