Biogenic monoamines in preimplantation development
Biogenic monoamines in preimplantation development
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DOI：
10.1093/humrep/der233
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发表时间：
2011-09-01
影响因子：
6.1
通讯作者：
Koppel, Juraj
中科院分区：
文献类型：
--
作者：
Cikos, Stefan;Fabian, Dusan;Koppel, Juraj
背景技术背景：生物单胺在早期（'preneural'）胚胎发生的参与已被很好地记录在较低的脊椎动物，但少得多的信息是关于这些分子在哺乳动物，包括human.METHODS的发展的最早阶段的作用：数据库（PubMed，ISI Web of Knowledge和Scopus）进行了搜索有关生物单胺在早期胚胎中发挥作用的研究。组胺，5-羟色胺和肾上腺素能受体在哺乳动物植入前发育过程中的表达的现有数据进行了总结，并在非常早期pregnancy.Results的生物源单胺的潜在作用进行了讨论：生物源单胺在哺乳动物植入前胚胎发育中的作用可以是多种多样的，这取决于胚胎发育阶段，和母体生物体的生理状态。几种生物源性单胺受体在植入前胚胎细胞中表达并具有生物学功能。组胺受体的激活在胚胎着床和滋养层浸润中发挥作用。肾上腺素能受体和5-羟色胺受体的激活可以影响早期胚胎细胞的增殖和存活。结论：生物源性单胺可以在生理条件下发挥重要作用，促进胚胎-母体相互作用，或者可以在不利或病理条件下影响早期胚胎（例如，在胚胎发育中）。G.在母亲的压力下，或者在服用某些抗抑郁药、抗偏头痛药或抗溃疡药的妇女中）。
BACKGROUND: The involvement of biogenic monoamines in early ('preneural') embryogenesis has been well documented in lower vertebrates, but much less information is available about the role of these molecules in the earliest stages of development in mammals, including humans.METHODS: Databases (PubMed, ISI Web of Knowledge and Scopus) were searched for studies relating to biogenic monoamines functioning in early embryos. The available data on the expression of histamine, serotonin and adrenergic receptors during mammalian preimplantation development were summarized, and the potential roles of biogenic monoamines in very early pregnancy were discussed.RESULTS: The roles of biogenic monoamines in mammalian preimplantation embryo development can be diverse, depending on the embryo developmental stage, and the physiological status of the maternal organism. Several receptors for biogenic monoamines are expressed and biologically functional in cells of preimplantation embryos. Activation of histamine receptors can play a role in embryo implantation and trophoblast invasion. Activation of adrenergic and serotonin receptors can influence proliferation and survival of early embryonic cells.CONCLUSIONS: Biogenic monoamines can play an important role in physiological conditions, contributing to embryo-maternal interactions, or can influence the early embryo under unfavorable or pathological conditions (e. g. in maternal stress, or in women taking certain antidepressants, anti-migraine or anti-ulcer drugs).