Common variants of FTO and the risk of obesity and type 2 diabetes in Indians
Common variants of FTO and the risk of obesity and type 2 diabetes in Indians
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DOI：
10.1038/jhg.2011.87
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发表时间：
2011-10-01
影响因子：
3.5
通讯作者：
Bharadwaj, Dwaipayan
中科院分区：
文献类型：
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作者：
Chauhan, Ganesh;Tabassum, Rubina;Bharadwaj, Dwaipayan
脂肪量和肥胖相关基因（FTO，fat mass- and obesity-associated gene）的常见变异已被证明与欧洲和非欧洲种族人群中的肥胖和2型糖尿病相关。然而，对印度人群的研究提供了不一致的结果。在这里，我们研究了8个FTO变异（rs 1421085，rs 8050136，rs 9939609，rs 9930506，rs 1861867，rs 9926180，rs 2540769和rs708277）与肥胖和2型糖尿病的关联5364名北印度人（2474名2型糖尿病患者和2890名非糖尿病对照）分两个阶段。包括先前报道的内含子1变体（rs 1421085、rs 8050136、rs 9939609和rs 9930506）在内的所有变体均未显示出与2型糖尿病的体重指数（BMI）依赖/独立关联。然而，在第2阶段和合并研究人群中，rs 1421085、rs 8050136和rs 9939609与肥胖状态和肥胖指标（BMI、腰围和腰臀比）相关。两个研究人群结果的荟萃分析还显示，在随机效应和固定效应模型下，rs 1421085、rs 8050136和rs 9939609与BMI显著相关（P（随机/固定）分别=0.02/0.0001、0.004/0.0006和0.01/0.01）。总之，在北印度人群中，FTO的常见变异与肥胖相关，但与2型糖尿病无关。Journal of Human Genetics（2011）56，720-726; doi：10.1038/jhg.2011.87; 2011年8月4日在线发表
Common variants of fat mass and obesity-associated gene (FTO, fat mass- and obesity-associated gene) have been shown to be associated with obesity and type 2 diabetes in population of European and non-European ethnicity. However, studies in Indian population have provided inconsistent results. Here, we examined association of eight FTO variants (rs1421085, rs8050136, rs9939609, rs9930506, rs1861867, rs9926180, rs2540769 and rs708277) with obesity and type 2 diabetes in 5364 North Indians (2474 type 2 diabetes patients and 2890 non-diabetic controls) in two stages. None of the variants including previously reported intron 1 variants (rs1421085, rs8050136, rs9939609 and rs9930506) showed body mass index (BMI)-dependent/independent association with type 2 diabetes. However, rs1421085, rs8050136 and rs9939609 were associated with obesity status and measures of obesity (BMI, waist circumference and waist-to-hip ratio) in stage 2 and combined study population. Meta-analysis of the two study population results also revealed that rs1421085, rs8050136 and rs9939609 were significantly associated with BMI both under the random-and fixed-effect models (P (random/fixed)=0.02/0.0001, 0.004/0.0006 and 0.01/0.01, respectively). In conclusion, common variants of FTO were associated with obesity, but not with type 2 diabetes in North Indian population. Journal of Human Genetics (2011) 56, 720-726; doi:10.1038/jhg.2011.87; published online 4 August 2011