Nutrition and the endothelium.
Nutrition and the endothelium.
复制标题
DOI：
10.1007/s11892-004-0076-7
复制
发表时间：
2004-08-01
影响因子：
4.2
通讯作者：
Hu, Frank B
中科院分区：
文献类型：
--
作者：
Lopez-Garcia, Esther;Hu, Frank B
越来越多的证据表明，饮食因素在调节内皮功能中起着重要作用。流行病学和临床研究表明，α -亚麻酸和长链n-3脂肪酸的摄入与降低炎症细胞因子和内皮粘附分子的血浆浓度有关，这两者都被认为是内皮功能障碍的标志。相反，反式脂肪酸摄入和较高的饮食血糖负荷与这些生物标志物的血浆浓度升高有关。最近，一些流行病学和干预研究已经检查了总体饮食模式和内皮功能障碍之间的关系。一般来说，“谨慎的饮食”，以摄入更多的水果、蔬菜、豆类、鱼、家禽和全谷物为特征，对内皮细胞有有益的影响。相反，“西方饮食”的特点是摄入更多的红肉和加工肉类、糖果、甜点、炸薯条和精制谷物，这与内皮功能的损害有关。这些发现为饮食因素影响心血管疾病风险提供了额外的生物学机制。
Growing evidence suggests that dietary factors play an important role in modulating endothelial function. Epidemiologic and clinical studies have related intake of alpha-linolenic acid and long-chain n-3 fatty acids to lower plasma concentrations of inflammatory cytokines and endothelial adhesion molecules, both of which are considered markers of endothelial dysfunction. In contrast, trans fatty acid intake and a higher dietary glycemic load have been associated with increased plasma concentrations of these biomarkers. Recently, several epidemiologic and intervention studies have examined the relationship between overall dietary patterns and endothelial dysfunction. In general, a "prudent diet," characterized by higher intake of fruits, vegetables, legumes, fish, poultry, and whole grains, is associated with a beneficial effect on the endothelium. Conversely, a "Western diet," characterized by higher intake of red and processed meats, sweets, desserts, French fries, and refined grains, is associated with an impairment of the endothelial function. These findings provide additional biological mechanisms through which dietary factors influence the risk of cardiovascular diseases.