Intestinal anti-inflammatory activity of apigenin K in two rat colitis models induced by trinitrobenzenesulfonic acid and dextran sulphate sodium
Intestinal anti-inflammatory activity of apigenin K in two rat colitis models induced by trinitrobenzenesulfonic acid and dextran sulphate sodium
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DOI：
10.1017/s0007114514004292
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发表时间：
2015-02-28
影响因子：
3.6
通讯作者：
Martinez-Augustin, Olga
中科院分区：
文献类型：
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作者：
Mascaraque, Cristina;Gonzalez, Raquel;Martinez-Augustin, Olga
类黄酮类化合物是自然界中广泛存在的多酚化合物，作为人类饮食的一部分大量食用。本研究的目的是在两种大鼠结肠炎模型，即三硝基苯磺酸(TNBS)模型和葡聚糖硫酸钠(DSS)模型上，检测芹菜素K的肠道抗炎活性。给TNBS和DSS结肠炎大鼠灌胃给予芹菜素K(1、3和10 mg/kg，每组4~6 mg/kg)，通过肉眼和生化检查检查结肠状况。芹菜素K预处理可改善TNBS模型的形态指标和生化指标。结果表明，与TNBS组相比，TNBS组的炎症面积缩小，计分和结肠重量/长度比降低。髓过氧化物酶(MPO)活性下降30%(P
Flavonoids are polyphenolic compounds that are widespread in nature, and consumed as part of the human diet in significant amounts. The aim of the present study was to test the intestinal anti-inflammatory activity of apigenin K, a soluble form of apigenin, in two models of rat colitis, namely the trinitrobenzenesulfonic acid (TNBS) model and the dextran sulphate sodium (DSS) model. Apigenin K (1, 3 and 10 mg/kg; by the oral route; n 4-6 per group) was administered as a pre-treatment to rats with TNBS and DSS colitis, and colonic status was checked by macroscopic and biochemical examination. Apigenin K pre-treatment resulted in the amelioration of morphological signs and biochemical markers in the TNBS model. The results demonstrated a reduction in the inflamed area, as well as lower values of score and colonic weight: length ratio compared with the TNBS group. Myeloperoxidase (MPO) activity was reduced by 30% (P