A caffeic acid mediated facile synthesis of silver nanoparticles with powerful anti-cancer activity
A caffeic acid mediated facile synthesis of silver nanoparticles with powerful anti-cancer activity
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DOI：
10.1016/j.colsurfb.2015.06.070
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发表时间：
2015-10-01
影响因子：
5.8
通讯作者：
Gu, Ning
中科院分区：
文献类型：
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作者：
Guo, Dawei;Dou, Dandan;Gu, Ning
随着纳米银(AgNPs)在生物医学领域的应用日益广泛，绿色合成，特别是在生物过程中的绿色合成受到越来越多的关注。然而，在大多数情况下，生物合成的AgNPs在大小和形状上都是异常的，并且在用于治疗时表现出一定的困难。我们使用咖啡酸，一种天然的植物多酚，在本研究中制备了AgNPs，并评价了它们对人肝癌HepG2细胞的抗癌活性。结果表明，以咖啡酸为还原剂和稳定剂，可以快速、简便地合成AgNPs。所合成的AgNPs具有尺寸小、分布窄、表面负电荷高、在水溶液中稳定等特点。此外，AgNPs可以进入细胞并通过诱导细胞凋亡有效地抑制肿瘤细胞的活性。综上所述，咖啡酸介导的简便方法成功地制备了AgNPs，作为一种潜在的人类肝癌治疗的替代药物。(C)2015爱思唯尔B.V.保留所有权利。
Green synthesis, especially in biological processes, has gained more attention with increasing application of silver nanoparticles (AgNPs) in biomedical fields. However, the biologically synthesized AgNPs have been to be anomalous in size and shape in most cases, as well as exhibiting certain difficulties when used in therapy. We used caffeic acid, a naturally plant polyphenol, to prepare the AgNPs in the current study and also evaluated their anti-cancer activity against the human hepatoma HepG2 cells. Results showed that the AgNPs could rapidly and simply be synthesized using caffeic acid as both a reducing agent and stabilizer. The synthesized AgNPs possessed characteristics of having small size, narrow distribution and high surface negative charge, as well as being stable in aqueous solution. Furthermore, the AgNPs could enter cells and effectively inhibit viability of tumor cells via induction of apoptosis. In conclusion, a caffeic acid mediated facile method was successfully developed to prepare the AgNPs as a potential alternative agent for human hepatoma therapy. (C) 2015 Elsevier B.V. All rights reserved.