Neuroethology of male courtship in Drosophila: from the gene to behavior.
Neuroethology of male courtship in Drosophila: from the gene to behavior.
复制标题
果蝇雄性求爱的神经行为学：从基因到行为。
DOI：
10.1007/s00359-014-0891-5
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
and Koganezawa M.
中科院分区：
文献类型：
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作者：
Yamamoto D.;Sato K.;and Koganezawa M.
果蝇（Drosophila melanogaster）的神经发生学分析显示，包括求偶在内的性别行为是由性二态神经回路支持的，其发育是由转录因子基因fruitless（fru）和doublex（dsx）以性别特异性的方式指导的，这两个基因是组成性别决定级联反应的核心成员。通过染色质修饰，在雄性神经系统中特异性翻译的Fru蛋白导致表达Fru的神经元承担雄性命运，如它们的雄性特异性存活或雄性特异性神经突形成所表现的。当雄性轻拍雌性腹部时，其中一个雄性特有的神经元群P1被激活。此外，当人工激活时，P1神经元足以诱导整个男性求偶仪式。这些研究为理解先天行为的遗传密码如何体现在神经元基质中提供了一个概念框架。
Neurogenetic analyses in the fruit flyDrosophila melanogasterrevealed that gendered behaviors, including courtship, are underpinned by sexually dimorphic neural circuitries, whose development is directed in a sex-specific manner by transcription factor genes,fruitless(fru) anddoublesex(dsx), two core members composing the sex-determination cascade. Via chromatin modification the Fru proteins translated specifically in the male nervous system lead thefru-expressing neurons to take on the male fate, as manifested by their male-specific survival or male-specific neurite formations. One such male-specific neuron group, P1, was shown to be activated when the male taps the female abdomen. Moreover, when artificially activated, P1 neurons are sufficient to induce the entire repertoire of the male courtship ritual. These studies provide a conceptual framework for understanding how the genetic code for innate behavior can be embodied in the neuronal substrate.