Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells
Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells
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DOI：
10.1016/j.immuni.2007.04.009
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发表时间：
2007-05-01
期刊：
影响因子：
32.4
通讯作者：
Finke, Daniela
中科院分区：
文献类型：
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作者：
Meier, Dominik;Bornmann, Caroline;Finke, Daniela
派尔集合淋巴结和淋巴结的形成需要CD 4（+）CD 3（-）IL-7 R α（+）淋巴组织诱导物（LTi）和VCAM-1（+）组织细胞之间的相互作用。在这里，我们表明，通过促进他们的生存，增强表达的白细胞介素-7（IL-7）在转基因小鼠导致LTi细胞的积累。随着IL-7可用性的增加，VCAM-11（+）派尔集合淋巴结原基的从头形成沿着整个胎儿肠道发生，导致派尔集合淋巴结数量增加5倍。IL-7过表达还导致形成多个有组织的异位淋巴结和盲肠斑。免疫后，异位淋巴结产生了正常的T细胞依赖性B细胞反应和生发中心。过表达IL-7但缺乏ROR γ（LTi细胞生成所需的因子）或α（1）β（2）O2的小鼠既没有派尔集合淋巴结，也没有异位淋巴结。因此，通过控制LTi细胞数量，IL-7可以调节正常和异位淋巴器官的形成。
Development of Peyer's patches and lymph nodes requires the interaction between CD4(+) CD3(-) IL-7R alpha(+) lymphoid-tissue inducer (LTi) and VCAM-1(+) organizer cells. Here we showed that by promoting their survival, enhanced expression of interleukin-7 (IL-7) in transgenic mice resulted in accumulation of LTi cells. With increased IL-7 availability, de novo formation of VCAM-11(+) Peyer's patch anlagen occurred along the entire fetal gut resulting in a 5-fold increase in Peyer's patch numbers. IL-7 overexpression also led to formation of multiple organized ectopic lymph nodes and cecal patches. After immunization, ectopic lymph nodes developed normal T cell-dependent B cell responses and germinal centers. Mice overexpressing IL-7 but lacking either ROR gamma, a factor required for LTi cell generation, or lymphotoxin alpha(1)beta(2) 02 had neither Peyer's patches nor ectopic lymph nodes. Therefore, by controlling LTi cell numbers, IL-7 can regulate the formation of both normal and ectopic lymphoid organs.