Metabolic and inflammatory functions of short-chain fatty acid receptors.
Metabolic and inflammatory functions of short-chain fatty acid receptors.
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DOI：
10.1016/j.coemr.2020.06.005
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发表时间：
2021-02-01
影响因子：
--
通讯作者：
Milligan, Graeme
中科院分区：
文献类型：
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作者：
Bolognini, Daniele;Dedeo, Domonkos;Milligan, Graeme
FFA2和FFA3是短链脂肪酸的受体，肠道细菌通过发酵消化不良的碳水化合物产生大量短链脂肪酸。随着新的药理工具和动物模型的产生和使用，对这些受体在调节肠道内分泌、代谢和免疫功能中的作用的了解已经得到了发展。目前正在出现一种复杂的(病理)生理学情景，其中FFA2和FFA3在关键细胞类型中的策略性表达和对其信号的选择性调节可能调节体重管理、能量平衡和炎症性疾病。
FFA2 and FFA3 are receptors for short-chain fatty acids which are produced in prodigious amounts by fermentation of poorly digested carbohydrates by gut bacteria. Understanding the roles of these receptors in regulating enteroendocrine, metabolic and immune functions has developed with the production and use of novel pharmacological tools and animal models. A complex (patho)physiological scenario is now emerging in which strategic expression of FFA2 and FFA3 in key cell types and selective modulation of their signalling might regulate body weight management, energy homoeostasis and inflammatory disorders.