Incorporation of micro-CT-based detailed bone models into ICRP adult mesh-type reference computational phantoms
Incorporation of micro-CT-based detailed bone models into ICRP adult mesh-type reference computational phantoms
复制标题
将基于微型 CT 的详细骨模型纳入 ICRP 成人网状参考计算模型
DOI：
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发表时间：
2022
影响因子：
3.5
通讯作者：
Chan Hyeong Kim
中科院分区：
文献类型：
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作者：
B. Shin;Y. Yeom;Chansoo Choi;W. Bolch;Haegin Han;T. Nguyen;Sungho Moon;Gahee Son;Suhyeon Kim;Hyeonil Kim;Chan Hyeong Kim
目标。红骨髓（RBM）和骨内皮（BE）是有效剂量计算所必需的，由于其微观和复杂的组织学，在国际放射防护委员会（ICRP）的参考图中进行了宏观建模。在本研究中，建立了详细的骨骼模型，以简化骨骼剂量学的剂量计算过程。的方法。详细的骨骼模型是在佛罗里达大学骨骼模型的基础上开发的。提出了一种利用虚拟子体素存储BE位置索引来更新BE区域定义的方法。然后通过Geant4代码的平行几何特征将详细的骨模型安装在ICRP网格型参考计算模型（MRCPs）的海绵状区域。主要的结果。将详细骨植入的MRCPs与原始MRCPs与海绵体吸收剂量和基于影响-剂量响应函数（DRF）的方法的结果进行比较，基于DRF的方法的差异要小得多，但仍然具有显著性。与ICRP出版物116和133给出的值相比，差异非常大（即几个数量级），主要是由于mrcp中骨骼系统的解剖改进；也就是说，在mrcp中，海绵和髓腔被皮质骨完全包围，但在ICRP-110中却没有。的意义。详细的骨模型可以直接计算RBM和BE的吸收剂量，简化剂量计算过程，并有可能提高骨骼剂量测定的一致性和准确性。
Objective. The red bone marrow (RBM) and bone endosteum (BE), which are required for effective dose calculation, are macroscopically modeled in the reference phantoms of the international commission on radiological protection (ICRP) due to their microscopic and complex histology. In the present study, the detailed bone models were developed to simplify the dose calculation process for skeletal dosimetry. Approach. The detailed bone models were developed based on the bone models developed at the University of Florida. A new method was used to update the definition of BE region by storing the BE location indices using virtual sub-voxels. The detailed bone models were then installed in the spongiosa regions of the ICRP mesh-type reference computational phantoms (MRCPs) via the parallel geometry feature of the Geant4 code. Main results. Comparing the results between the detailed-bone-installed MRCPs and the original MRCPs with the absorbed dose to spongiosa and fluence-to-dose response function (DRF)-based methods, the DRF-based method showed much smaller but still significant differences. Compared with the values given in ICRP Publications 116 and 133, the differences were very large (i.e. several orders of magnitudes), due mainly to the anatomical improvement of the skeletal system in the MRCPs; that is, spongiosa and medullary cavity are fully enclosed by cortical bone in the MRCPs but not in the ICRP-110 phantoms. Significance. The detailed bone models enable the direct calculation of the absorbed doses to the RBM and BE, simplifying the dose calculation process and potentially improving the consistency and accuracy of skeletal dosimetry.