Treatment of human periodontal infrabony defects with hydroxyapatite + beta tricalcium phosphate bone graft alone and in combination with platelet rich plasma: a randomized clinical trial.
Treatment of human periodontal infrabony defects with hydroxyapatite + beta tricalcium phosphate bone graft alone and in combination with platelet rich plasma: a randomized clinical trial.
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DOI：
10.4103/0970-9290.90278
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发表时间：
2011-07-01
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影响因子：
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通讯作者：
Varghese, Sheeja
中科院分区：
文献类型：
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作者：
Kaushick, Bharadwaj T;Jayakumar, N D;Varghese, Sheeja
背景技术背景：本研究旨在比较两种再生技术的临床效果-富血小板血浆（PRP）+骨移植（HA + β TCP）与骨移植（HA + β TCP）+生理盐水在牙周骨内deficiency.MATERIALS和METHODS：10例诊断为慢性牙周炎的患者参加了一个随机的分裂口临床试验。I期治疗后，将这些部位随机分配至试验组- PRP +植骨（HA + β TCP）和对照组-生理盐水+植骨（HA + β TCP）。在基线和6个月时记录的临床参数包括菌斑指数、探诊袋深度、相对附着水平和相对龈缘水平。使用数字X线摄影进行硬组织评价，以评价图像强度，从而评价骨内缺损中所需关注区域的射线不透性。治疗组之间在6 months.RESULTS：试验组网站显示了一个显着较高的减少袋深度相比，对照组网站前和术后比较。测试组网站表现出显着更高的量的射线不透性在感兴趣的区域，表明更好的移植物重塑，相比对照组sites.CONCLUSION：（HA + β TCP）骨移植似乎是一个有益的材料在治疗人牙周骨内缺损。当与富含血小板的血浆结合时，在骨内缺损中观察到的探测囊袋深度的减少显著更高，附着水平的增加更高，放射密度的量更高。
BACKGROUND: The present study was aimed at comparing the clinical effectiveness of two regenerative techniques - platelet rich plasma (PRP) + bone graft (HA + beta TCP) versus bone graft (HA + beta TCP) + normal saline in the treatment of periodontal intrabony defects.MATERIALS AND METHODS: Ten patients diagnosed with chronic periodontitis were enrolled in a randomized split mouth clinical trial. Following phase I therapy the sites were randomly assigned to the test group - PRP + bone graft (HA + beta TCP) and control group - saline + bone graft (HA + beta TCP). Clinical parameters recorded at baseline and 6 months included plaque index, probing pocket depth, relative attachment levels, and relative gingival margin levels. Hard tissue evaluation was done using digital radiography to evaluate the image intensity and therefore the radioopacity of a desired region of interest in the intrabony defect. Pre- and postoperative comparisons were made between the treatment groups at 6 months.RESULTS: Test group sites showed a significantly higher reduction in pocket depth compared to control group sites. Test group sites showed a significantly higher amount of radioopacity in the regions of interest, indicative of better graft remodeling, compared to control group sites.CONCLUSION: (HA + beta TCP) bone graft appears to be a beneficial material in the treatment of human periodontal intrabony defects. When combined with platelet-rich plasma there is a significantly higher reduction in probing pocket depth, higher gain in attachment levels and higher amount of radio-density seen in the intrabony defects.