Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats
Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats
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DOI：
10.1161/hy1201.096576
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发表时间：
2001-12-01
期刊：
影响因子：
8.3
通讯作者：
Siragy, HM
中科院分区：
文献类型：
--
作者：
Carey, RM;Howell, NL;Siragy, HM
2型（AT(2)）血管紧张素（Ang） II受体被认为对Ang II对其1型（AT(1)）受体的作用具有潜在的反调节作用。我们研究了Ang II和CGP- 42112a (CGP)，一种选择性肽AT，受体激动剂的作用。用氯沙坦（LOS）或缬沙坦（VAL）阻断或不阻断AT受体的大鼠的血压（BP）。在接受正常钠摄入量的麻醉大鼠（每组n=5）中，仅Ang II （200 pmol/kg每分钟IV）就使血压从对照的112 +/- 3升高到168 +/- 7 mm Hg (P
The type-2 (AT(2)) angiotensin (Ang) II receptor has been characterized as potentially counterregulatory to the actions of Ang II at its type-1 (AT(1)) receptor. We investigated the effects of Ang II and CGP-42112A (CGP), a selective peptide AT, receptor agonist. on blood pressure (BP) in rats with or without pharmacological blockade of the AT, receptor with losartan (LOS) or valsartan (VAL). In anesthetized rats (n=5 per group) receiving normal sodium intake, Ang II (200 pmol/kg per minute IV) alone increased BP from a control of 112 +/- 3 to 168 +/- 7 mm Hg (P