Tumour necrosis factor-alpha plasma levels in elderly patients with Type 2 diabetes mellitus - observations over 2 years
Tumour necrosis factor-alpha plasma levels in elderly patients with Type 2 diabetes mellitus - observations over 2 years
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DOI：
10.1046/j.1464-5491.2002.00846.x
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发表时间：
2002-11-01
影响因子：
3.5
通讯作者：
Dzien, A
中科院分区：
文献类型：
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作者：
Lechleitner, M;Herold, M;Dzien, A
肿瘤坏死因子-α（TNF-α）参与肥胖相关胰岛素抵抗的发展。TNF-α血浆水平随着年龄的增长而升高，因此也可能与2型糖尿病的代谢控制有关。我们研究了2年以上老年2型糖尿病患者血浆TNF-α水平与血糖控制的关系。方法对53例2型糖尿病患者（平均年龄71.6 ± 5.6岁）的临床和实验室资料进行了2年以上的定期评估，并分析了其与抗糖尿病治疗方案的关系。结果TNF-α血浆水平从基线时的16.2 ± 9.6 pg/ml显著增加到2年后的28.0 ± 13.8 pg/ml（P=0.028）。HbA（1c）值也从6.4+/-1.2%增至7.7+/-1.6%（P=0.046）。患者的平均体重指数几乎保持不变，但观察到体脂百分比（34.5+/-7.0%至35.3+/-6.9%; P=0.061）和腰臀比（0.86+/-0.04至0.88+/-0.04; P=0.052）适度增加。校正协变量后，多变量分析表明，TNF-α血浆水平与基线对照和2年后整个研究人群的HbA（1c）值呈正相关。TNF-α也揭示了一个正相关的身体fat.Conclusions的百分比在老年2型糖尿病患者TNF-α血浆水平显示在2年的观察期内持续增加。这种TNF-α血浆水平的增加可能增加了2型糖尿病进展中血糖控制恶化的另一个方面。
Aims The cytokine tumour necrosis factor-alpha (TNF-alpha) is involved in the development of obesity-linked insulin resistance. TNF-alpha plasma levels rise with increasing age and might thus also be related to metabolic control in Type 2 diabetes mellitus. We have studied the relationship of TNF-alpha plasma levels to glycaemic control in elderly patients with Type 2 diabetes over 2 years.Methods Clinical and laboratory data of 53 patients (26 women, 27 men) with Type 2 diabetes (mean age 71.6+/-5.6 years) were regularly evaluated over 2 years, and the relationship to anti-diabetic treatment regimens analysed. TNF-alpha plasma level was measured by a solid-phase enzyme amplified sensitivity immunoassay.Results TNF-alpha plasma levels increased significantly from 16.2+/-9.6 pg/ml at baseline to 28.0+/-13.8 pg/ml after 2 years (P=0.028). HbA(1c) values also increased from 6.4+/-1.2% to 7.7+/-1.6% (P=0.046). Mean body mass index of the patients remained almost constant, while a moderate increase in the percentage of body fat (34.5+/-7.0% to 35.3+/-6.9%; P=0.061) and in waist-hip ratio was observed (0.86+/-0.04 to 0.88+/-0.04; P=0.052). After adjustment for covariates multivariate analysis demonstrated that TNF-alpha plasma levels are positively related to the HbA(1c) values of the whole study population at the baseline control and after 2 years. TNF-alpha also revealed a positive correlation to the percentage of body fat.Conclusions In elderly patients with Type 2 diabetes TNF-alpha plasma levels revealed a continuous increase during an observation period of 2 years. This increase in TNF-alpha plasma levels might add another aspect to the worsening of glycaemic control in the progression of Type 2 diabetes.