The role of miRNAs and EBV BARTs in NPC.

The role of miRNAs and EBV BARTs in NPC.
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DOI:
10.1016/j.semcancer.2011.12.001
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发表时间:
2012-04
影响因子:
14.5
通讯作者:
Raab-Traub N
Raab-Traub N
中科院分区:
医学1区
文献类型:
--
作者:
Marquitz AR;Raab-Traub N

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BamH Ⅰ A转录本是由EB病毒产生的一组选择性剪接转录本,在鼻咽癌中高度表达。这些转录物含有几个开放阅读框以及22个miRNA的前体。虽然尚未检测到对应于这些开放阅读框的推定蛋白质,但几项研究已经鉴定了关于细胞转化的有趣且潜在重要的性质。然而,miRNA在所有鼻咽癌中非常丰富,并且已经鉴定了一些miRNA的几种潜在的重要功能。这篇文章将集中在这一复杂的转录本集的性质和证据表明,他们有助于鼻咽癌的发展。
The BamHI A Rightward Transcripts are a set of alternatively splicing transcripts produced by Epstein-Barr Virus that are highly expressed in nasopharyngeal carcinoma. These transcripts contain several open reading frames as well as precursors for twenty two miRNAs. Although the putative proteins corresponding to these open reading frames have not been detected, several studies have identified properties that are interesting and potentially significant with respect to cellular transformation. The miRNAs, however, are very abundant in all nasopharyngeal carcinomas and several potentially significant functions have been identified for some of the miRNAs. This article will focus on the nature of this complicated set of transcripts and the evidence that they contribute to the development of nasopharyngeal carcinoma.
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