Conductive interstitial hyperthermia in the treatment of intracranial metastatic disease
Conductive interstitial hyperthermia in the treatment of intracranial metastatic disease
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传导性间质热疗治疗颅内转移性疾病
DOI：
10.1007/bf01054769
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发表时间：
1995
影响因子：
3.9
通讯作者：
N. Fearnot
中科院分区：
文献类型：
--
作者：
C. Moran;J. A. Marchosky;F. Wippold;J. Deford;N. Fearnot
背景在美国，颅内转移通常使肿瘤治疗复杂化，每年影响140,000名患者。这些肿瘤的治疗很困难，而且往往不成功。热疗是一种治疗替代方案，在其他领域的癌症治疗中显示出了希望。方法对13例复发或进展性颅内转移瘤患者进行了间质热疗的I期和II期临床试验，以评估并发症、热量传递和患者结局。结果未发生临床上有意义的出血、肿块增大或感染等并发症，并进行了治疗。4例患者癫痫发作经加用抗惊厥药物控制。3例静脉血栓栓塞症患者接受药物治疗和经皮下腔静脉滤器置入治疗。大多数患者的KPS在治疗后略有下降，但在几个月内反弹到接近基线。CT扫描显示13例患者中有7例肿瘤体积缩小或稳定。结论间质热疗治疗颅内转移瘤在技术上是可行的，可提高肿瘤控制率。在这个小系列中，它没有造成不合理的并发症。这种疗法有一些积极的效果，但在明确其作用之前，需要对更多的患者进行研究。正在评估热疗与近距离放射治疗和/或化疗的结合。本文中包含的观点和断言是作者的私人观点，不应被解释为官方或反映国防部的观点。
SummaryBackgroundIntracranial metastases commonly complicate oncologic care affecting 140,000 patients per year in the United States. Treatment of these tumors is difficult and often unsuccessful. Hyperthermia is a treatment alternative that has shown promise in treating cancer in other areas. Therefore it was employed in an attempt to provide increased tumor control in CNS metastases.MethodsThis Phase I and Phase II clinical trial of interstitial hyperthermia in 13 patients with recurrent or progressive intracranial metastatic disease was undertaken to evaluate complications, delivery of heat and patient outcome.ResultsFeared complications of clinically significant bleeding, increased mass, or infection from the interstitial implant and treatment did not occur. The seizures which occurred in 4 patients were controlled with additional anticonvulsants. Three venous thromboembolic events were treated medically and with percutaneously placed inferior vena cava filters. The KPS of the majority of patients declined slightly with treatment but rebounded to near baseline within several months. CT scans demonstrated decrease or stabilization of tumor volumes in 7 of the 13 patients. In 4 of these patients, regression or stabilization persisted until death from nonCNS disease.ConclusionsInterstitial hyperthermia therapy for intracranial metastases is technically feasible and may provide increased tumor control. In this small series, it did not cause unreasonable complications. This therapy has some positive effect, but requires study of more patients before its role is definitively known. Combining hyperthermia with brachytherapy and/or chemotherapy is being evaluated.The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of Defense.
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间质照射和热疗用于治疗复发性恶性脑肿瘤。
影响因子：
4.8
作者：
Sneed,PK;Stauffer,PR;Gutin,PH;Phillips,TL;Suen,S;Weaver,KA;Lamb,SA;Ham,B;Prados,MD;Larson,DA
通讯作者：
Larson,DA
低温和高温对大鼠体外脑小动脉反应性的影响。
影响因子：
4.1
作者：
Ogura,K;Takayasu,M;DaceyJr,RG
通讯作者：
DaceyJr,RG
热与放疗和化疗的相互作用。
影响因子：
11.2
作者：
Dewey,WC
通讯作者：
Dewey,WC
与 HeLa S3 细胞缺乏慢性耐热性表达相关的细胞机制。
影响因子：
11.2
作者：
Mackey,MA;Anolik,SL;RotiRoti,JL
通讯作者：
RotiRoti,JL
复发性恶性脑肿瘤的热放射治疗。
DOI：
10.1016/0360-3016(92)90659-6
发表时间：
1992
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Sneed,PK;Gutin,PH;Stauffer,PR;Phillips,TL;Prados,MD;Weaver,KA;Suen,S;Lamb,SA;Ham,B;Ahn,DK
通讯作者：
Ahn,DK