Effects of stimulus rate on the feline brain-stem auditory evoked response during development .1. Peak latencies
Effects of stimulus rate on the feline brain-stem auditory evoked response during development .1. Peak latencies
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DOI：
10.1121/1.416209
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发表时间：
1996-08-01
影响因子：
2.4
通讯作者：
Walsh, EJ
中科院分区：
文献类型：
--
作者：
Burkard, R;McGee, J;Walsh, EJ
本文研究了刺激频率对发育期和成年猫脑干听觉诱发反应（BAER）的影响。年龄范围从出生后10天到年轻成年人。以90 dB pSPL和每只动物的咔哒声阈值以上20 dB（20 dB SI）的水平呈现咔哒声。对于所有动物，以5、10、30、60和90 Hz的频率获得常规BAER结局系列。BAER也使用称为最大长度序列（MLS）的伪随机脉冲序列获得。脉冲之间的最小时间，最小脉冲间隔（MPI），包括0.5、1、2、4和6 ms，分别对应于1000、500、250、125和83 Hz的平均频率。因变量包括前四个BAER峰（标记为i至iv）的峰值。MLS BAER在所有研究年龄段与传统BAER无明显区别。一般而言，对于常规和MLS BAER，峰值潜伏期和i-iv间期随着刺激率的增加而增加。虽然绝对峰潜伏期和i-iv间期随年龄的增长而系统性地下降，但在发育过程中，由增加刺激率引起的潜伏期和i-iv间期的相对偏移量下降。在年轻时观察到的对刺激率的敏感性增强并不是在发育过程中发生的阈值改善的结果，因为当刺激以恒定的绝对水平（90 dB pSPL）或阈值以上的恒定水平（20 dB SL）呈现时，也进行了类似的观察。此外，连续的BAER峰表现出越来越大的潜伏期的变化，增加刺激率在所有年龄的研究。这些数据表明，较高的刺激率产生更大的神经适应，导致延长BAER峰值潜伏期。此外，适应的影响是累积的突触，和机制负责收购成人一样的适应性能的发展过程中出生后早期的猫。（C）1996年美国声学学会。
The effects of stimulation rate on the brain-stem auditory evoked response (BAER) of developing and adult cats were investigated. Age ranged from 10-post-natal days to young adults. Clicks were presented at levels of 90 dB pSPL and 20 dB above each animal's click threshold (20 dB SI,). For all animals, a conventional BAER fate series was obtained at rates of 5, 10, 30, 60, and 90 Hz. BAERs were also obtained using pseudorandom pulse sequences called maximum length sequences (MLSs). The minimum time between pulses, the minimum pulse interval (MPI), included 0.5, 1, 2, 4, and 6 ms, which correspond to average rates of 1000, 500, 250, 125, and 83 Hz, respectively. Dependent variables included the latencies of the first four BAER peaks, labeled i through iv. MLS BAERs were indistinguishable from conventional BAERs at all ages studied. In general, for both conventional and MLS BAERs, peak latencies and the i-iv interval increased with increasing stimulus rate. Although absolute peak latencies and the i-iv interval decreased systematically with age, the relative shift in latency and i-iv interval induced by increasing stimulus rate decreased during development. The enhanced sensitivity to stimulus rate observed at younger ages was not the consequence of the threshold improvement that occurs during development since similar observations were made when stimuli were presented at a constant absolute level (90 dB pSPL) or at a constant level above threshold (20 dB SL). In addition, successive BAER peaks exhibited progressively larger latency shifts with increasing stimulus rate at all ages studied. These data suggest that higher stimulus rates produce greater neural adaptation resulting in prolonged BAER peak latencies. Furthermore, the effects of adaptation are cumulative across synapses, and the mechanisms responsible for the acquisition of adult-like adaptation properties develop during the early post-natal period in the cat. (C) 1996 Acoustical Society of America.