β-carotene 15,15′-dioxygenase activity in streptozotocin-induced diabetic rats
β-carotene 15,15′-dioxygenase activity in streptozotocin-induced diabetic rats
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DOI：
10.3177/jnsv.46.263
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发表时间：
2000-10-01
影响因子：
1.6
通讯作者：
Tamai, H
中科院分区：
文献类型：
--
作者：
Morinobu, T;Tamai, H
我们测量了链脲佐菌素诱导的糖尿病大鼠的视黄醇水平和 β-胡萝卜素 15,15'-双加氧酶活性，以评估该疾病与 β-胡萝卜素转化为视黄醇之间的关系。糖尿病大鼠血浆视黄醇水平显着低于对照大鼠，但肝脏视黄醇水平显着高于对照大鼠。糖尿病大鼠的肝脏双加氧酶活性显着低于对照大鼠，但肠粘膜的双加氧酶活性则不然。肝脏双加氧酶活性与肝脏视黄醇水平呈显着负相关，结果表明糖尿病大鼠肝脏中视黄醇的分泌受到干扰，并且肝脏中视黄醇增加抑制了肝脏双加氧酶活性。
We measured retinol levels and beta -carotene 15,15'-dioxygenase activity in rats with streptozotocin-induced diabetes mellitus to assess the relationship between the disease and the conversion of beta -carotene to retinol. The plasma retinol level was significantly lower in diabetic rats than in control rats, but the hepatic retinol level was significantly higher than the control. The hepatic dioxygenase activity but not that of the intestinal mucosa, was significantly lower in diabetic rats than in control rats. The hepatic dioxygenase activity showed a significant negative correlation with the hepatic retinol levels, The results suggest the disturbed secretion of retinol from the liver and suppression of hepatic dioxygenase activity by the retinol increased in the liver in diabetic rats.