Concerted deletions and inversions are caused by mitotic recombination between delta sequences in Saccharomyces cerevisiae.
Concerted deletions and inversions are caused by mitotic recombination between delta sequences in Saccharomyces cerevisiae.
复制标题
协同缺失和倒位是由酿酒酵母中 delta 序列之间的有丝分裂重组引起的。
DOI：
10.1128/mcb.7.3.1198-1207.1987
复制
发表时间：
1987
影响因子：
5.3
通讯作者：
Rosenberg,N
中科院分区：
文献类型：
--
作者：
Rothstein,R;Helms,C;Rosenberg,N
Deletions of a tyrosine tRNA suppressor gene,SUP4-o, are mediated by recombination between short repeated delta sequences inSaccharomyces cerevisiae. The arrangement of the five solo delta sequences that surround theSUP4locus was established by DNA sequence analysis. Seven deletion classes were identified by genomic blotting. DNA sequence analysis also showed that the delta sequences within a 6.5-kilobase region of theSUP4locus were the endpoints of these events. In three of these classes, an adjacent interval surrounded by delta sequences was inverted in concert with the deletion. The frequency of all deletion classes decreased in strains that contained mutations in the recombination and repair geneRAD52. We present two gene conversion mechanisms by which these rearrangements could have been generated. These models may also explain deletions between repeated sequences in other systems.
