Metal-Containing Schiff Base/Sulfoxide Ligands for Pd(II)-Catalyzed Asymmetric Allylic C-H Aminations
Metal-Containing Schiff Base/Sulfoxide Ligands for Pd(II)-Catalyzed Asymmetric Allylic C-H Aminations
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DOI：
10.1021/acscatal.0c05261
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发表时间：
2021-02-12
期刊：
影响因子：
12.9
通讯作者：
Matsunaga, Shigeki
中科院分区：
文献类型：
--
作者：
Bunno, Youka;Tsukimawashi, Yuta;Matsunaga, Shigeki
以含金属席夫碱/亚砜为手性配体，研究了Pd（II）催化的不对称烯丙基C-H胺化反应。使用含金属的席夫碱配体允许调节Pd（II）-催化剂的选择性和反应性，其中席夫碱-Cu（II）/亚砜配体与Pd（OAc）（2）的组合显示出最佳性能。C-H胺化产物的产率可达91：9。
Metal-containing Schiff base/sulfoxides were developed as chiral ligands for Pd(II)-catalyzed asymmetric intramolecular allylic C-H amination reactions. The use of metal-containing Schiff base ligands allows tuning the selectivity and reactivity of the Pd(II)-catalyst, whereby a Schiff base-Cu(II)/sulfoxide ligand in combination with Pd(OAc)(2) showed the best performance. Both internal and terminal alkenes were applicable, and the C-H amination products were obtained in up to 91:9 er.