Pain management via local anesthetics and responsive hydrogels.
Pain management via local anesthetics and responsive hydrogels.
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DOI：
10.4155/tde.14.95
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发表时间：
2015-02
影响因子：
4.2
通讯作者：
Nair LS
中科院分区：
文献类型：
--
作者：
Bagshaw KR;Hanenbaum CL;Carbone EJ;Lo KW;Laurencin CT;Walker J;Nair LS
急性和慢性疼痛控制是一项重大的临床挑战，在很大程度上尚未得到满足。局部麻醉药广泛应用于手术后疼痛的控制以及急性和慢性疼痛的治疗。虽然目前有多种方法用于延长局部麻醉剂的作用时间，但尚未确定一种最佳策略，可以在几小时到几天内以最小的毒性实现神经阻塞。一些药物递送系统，如脂质体、微颗粒和纳米颗粒，已被研究作为局部麻醉递送载体，以实现长时间麻醉。最近，可注射反应性水凝胶引起了麻醉分子局部递送的极大兴趣。本文讨论了可注射水凝胶延长局麻药作用的潜力。
Acute and chronic pain control is a significant clinical challenge that has been largely unmet. Local anesthetics are widely used for the control of post-operative pain and in the therapy of acute and chronic pain. While a variety of approaches are currently used to prolong the duration of action of local anesthetics, an optimal strategy to achieve neural blockage for several hours to days with minimal toxicity has yet to be identified. Several drug delivery systems such as liposomes, microparticles and nanoparticles have been investigated as local anesthetic delivery vehicles to achieve prolonged anesthesia. Recently, injectable responsive hydrogels raise significant interest for the localized delivery of anesthetic molecules. This paper discusses the potential of injectable hydrogels to prolong the action of local anesthetics.