Evidence that E-cadherin may be a target for cadmium toxicity in epithelial cells.
Evidence that E-cadherin may be a target for cadmium toxicity in epithelial cells.
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DOI：
10.1006/taap.2000.8905
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发表时间：
2000-05
影响因子：
3.8
通讯作者：
W. Prozialeck
中科院分区：
文献类型：
--
作者：
W. Prozialeck
E-钙粘附素是一种钙离子依赖的细胞黏附分子，在上皮极性和屏障功能的发育和维持中发挥重要作用。本文介绍了近年来有关环境污染物Cd(2+)损伤多种上皮细胞间E-钙粘素依赖性连接的研究结果，并对Cd(2+)与E-钙粘蛋白分子直接相互作用的证据进行了综述。此外，本文还讨论了Cd(2+)对肺、肾、骨和血管内皮细胞等特定靶器官的毒性机制。
E-cadherin is a Ca(2+)-dependent cell adhesion molecule that plays an important role in the development and maintenance of epithelial polarity and barrier function. This commentary describes the results of recent studies showing that the environmental pollutant Cd(2+) can damage the E-cadherin-dependent junctions between many types of epithelial cells and reviews the evidence indicating that this effect results from the direct interaction of Cd(2+) with the E-cadherin molecule. In addition, the implications of these findings with respect to the mechanisms of Cd(2+) toxicity in specific target organs such as lung, kidney, bone, and the vascular endothelium are discussed.