Optimization of Gold Nanoparticle Synthesis in Continuous‐Flow Micromixers Using Response Surface Methodology
Optimization of Gold Nanoparticle Synthesis in Continuous‐Flow Micromixers Using Response Surface Methodology
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DOI：
10.1002/ceat.202000314
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发表时间：
2021-02
影响因子：
2.1
通讯作者：
Marissa C. Sarsfield;A. Roberts;K. Streletzky;P. Fodor;C. Kothapalli
中科院分区：
文献类型：
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作者：
Marissa C. Sarsfield;A. Roberts;K. Streletzky;P. Fodor;C. Kothapalli
利用响应面法（RSM）在微流控混合器中合成了金纳米颗粒（AuNPs）。采用反向交错的人字槽型微混合器，改变反应温度、反应物浓度比、雷诺数和氯金酸的pH值，得到所需的反应是粒径和紫外光谱峰强度。通过同时优化变量范围来确定多项式方程与实验数据的最佳拟合。结果揭示了各反应变量对粒径和UV峰强度的个体和协同作用，从而确定了最大的设计空间。在蛇纹石混合器中确定了反应变量对AuNP合成和粒度的影响。
Gold nanoparticles (AuNPs) were synthesized in microfluidic mixers by means of response surface methodology (RSM). A reverse‐staggered herringbone micromixer was employed and reaction temperature, concentration ratio of reactants, Reynolds number, and pH of chloroauric acid were varied, with desired responses being particle size and peak intensity from UV spectroscopy. RSM was performed by simultaneously optimizing variable ranges to identify the best fit of polynomial equations to experimental data. Results revealed the individual and synergistic roles of each reaction variable on particle size and UV peak intensity, leading to identification of the largest design space. The effect of reaction variables on AuNP synthesis and particle size was confirmed in serpentine mixers.