Effects of the Space Flight Environment on the Immune System
Effects of the Space Flight Environment on the Immune System
复制标题
DOI：
10.1515/reveh.2003.18.1.1
复制
发表时间：
2003
影响因子：
3.9
通讯作者：
G. Sonnenfeld;J. Butel;W. Shearer
中科院分区：
文献类型：
--
作者：
G. Sonnenfeld;J. Butel;W. Shearer
空间飞行条件对哺乳动物的各种生理功能，包括肌肉、骨骼和神经前庭功能有显著影响。当人类或动物暴露于空间飞行条件时，受影响的生理功能之一是免疫反应。这次审查的重点是在实际的空间飞行，以及在地球上的空间飞行条件下的模型中的免疫系统在空间飞行条件下的功能。实验在组织培养系统、动物模型和人类受试者中进行。结果表明，空间飞行条件改变了细胞介导的免疫反应，包括淋巴细胞增殖和亚群分布，以及细胞因子的产生。空间飞行引起免疫系统功能改变的机制仍有待确定。然而，可能有多种因素，包括微重力、压力、神经内分泌因素、睡眠中断和营养因素，参与改变免疫系统的某些功能。这种改变可能导致对感染和肿瘤的防御能力受损。
Space flight conditions have a dramatic effect on a variety of physiologic functions of mammals, including muscle, bone, and neurovestibular function. Among the physiological functions that are affected when humans or animals are exposed to space flight conditions is the immune response. The focus of this review is on the function of the immune system in space flight conditions during actual space flights, as well as in models of space flight conditions on the earth. The experiments were carried out in tissue culture systems, in animal models, and in human subjects. The results indicate that space flight conditions alter cell-mediated immune responses, including lymphocyte proliferation and subset distribution, and cytokine production. The mechanism(s) of space flight-induced alterations in immune system function remain(s) to be established. It is likely, however, that multiple factors, including microgravity, stress, neuroendocrine factors, sleep disruption, and nutritional factors, are involved in altering certain functions of the immune system. Such alterations could lead to compromised defenses against infections and tumors.