Bleomycin-induced alveolitis detected by FDG positron emission tomography.
Bleomycin-induced alveolitis detected by FDG positron emission tomography.
复制标题
通过 FDG 正电子发射断层扫描检测博莱霉素诱导的肺泡炎。
DOI：
10.1097/00003072-200207000-00013
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发表时间：
2002
影响因子：
10.6
通讯作者：
A. Beggs
中科院分区：
文献类型：
--
作者：
S. Hain;A. Beggs
博莱霉素化疗可引起肺泡炎，危险因素包括年龄较大（>70岁）和大剂量（>400U）。氟脱氧葡萄糖正电子发射断层扫描 (FDG PET) 越来越多地用于监测淋巴瘤的治疗。作者描述了两名患者，在博莱霉素治疗后，FDG-PET 图像上发现弥漫性摄取。由于 PET 能够检测早期代谢变化，因此比其他成像方法（例如胸片）更早地发现异常。排除肺泡炎的其他原因。化疗后肺部 FDG 摄取增加的弥漫性模式可能表明博莱霉素诱导的毒性。
Bleomycin chemotherapy can cause alveolitis, and risk factors include older age (> 70 years) and large dose (> 400 U). Fluorodeoxyglucose positron emission tomography (FDG PET) is being used increasingly to monitor therapy in lymphoma. The authors describe two patients in whom diffuse uptake was seen on FDG-PET images after bleomycin treatment. Because of its ability to detect early metabolic changes, PET showed abnormalities earlier than did other imaging methods, such as chest radiographs. Other causes of alveolitis were excluded. A diffuse pattern of increased FDG uptake in the lungs after chemotherapy may be indicative of bleomycin-induced toxicity.