SOCIAL MODEL OF DEPRESSION IN MICE OF C57BL/6J STRAIN
SOCIAL MODEL OF DEPRESSION IN MICE OF C57BL/6J STRAIN
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DOI：
10.1016/0091-3057(91)90284-9
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发表时间：
1991-02-01
影响因子：
3.6
通讯作者：
KORYAKINA, LA
中科院分区：
文献类型：
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作者：
KUDRYAVTSEVA, NN;BAKSHTANOVSKAYA, IV;KORYAKINA, LA
在日常社会雄性间对抗中长期失败的经验以及在感官接触条件下与攻击性雄性长期生活[Kudryavtseva（8）]已被证明会导致C57 BL/6 J品系雄性小鼠顺从行为模式的变化。在20次失败后，顺从的雄性表现出被动的防御姿态，而不是他们在第一次遭遇时表现出的主动防御和退缩。此外，出现了新的不动姿势，这在第一次对抗中非常罕见。顺从动物在旷场试验中表现出安培数减少，在Porsolt试验中表现出不动时间增加。丙咪嗪的慢性治疗防止了通过Porsolt试验估计的“抑郁”的增加。体重减轻，胃肠道功能出现一些紊乱。数据进行了讨论，在顺从的雄性C57 BL/6 J小鼠的抑郁症的发展，由于慢性不可避免的社会压力。
Long experience of defeat in daily social intermale confrontations and permanent living with aggressive males under sensory contact conditions [Kudryavtseva (8)] has been shown to produce changes in the patterns of submissive behavior of male mice of C57BL/6J strain. The submissive males after 20 defeats demonstrated passive defense postures instead of active defense and withdrawal which they had displayed in first encounters. Moreover, new immobile postures appeared, which were very rare in the first confrontations. Submissive animals displayed a decrease of ambulation in the open-field test and increase the immobility time in the Porsolt's test. Chronic treatment with imipramine prevented the increase of "depressiveness" estimated by means of the Porsolt's test. There was a loss of weight and some disturbances in gastrointestinal functions. The data are discussed in terms of the development of depression in submissive male C57BL/6J mice as a result of chronic unavoidable social stress.