200 Million Thymocytes and I: A Beginner's Survival Guide to T Cell Development
200 Million Thymocytes and I: A Beginner's Survival Guide to T Cell Development
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DOI：
10.1007/978-1-4939-2809-5_1
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发表时间：
2016-01-01
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影响因子：
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通讯作者：
Bosselut, Remy
中科院分区：
文献类型：
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作者：
Vacchio, Melanie S.;Ciucci, Thomas;Bosselut, Remy
T淋巴细胞（T细胞）对适当的适应性免疫反应至关重要。它们在防御病原体方面发挥多种功能，特别是积极或消极地控制参与免疫反应的其他细胞。T细胞在胸腺中由骨髓来源的前体发育而来。这些前体（胸腺细胞）增殖，重组编码T细胞抗原受体亚基的基因，使其具有独特的抗原特异性，并经历不同程度的预编程，以实现其在免疫应答中的功能。因此，分析胸腺中的T细胞发育对于理解它们在免疫应答中的功能是必不可少的。此外，胸腺是分析细胞增殖、分化和存活机制的一个有吸引力的实验模型，这些机制都参与了胸腺细胞的发育。本章简要介绍了胸腺内T细胞发育的关键事件，作为进入这一研究领域的读者的介绍。
T lymphocytes (T cells) are essential for proper adaptive immune responses. They perform a variety of functions in defenses against pathogens, and notably control, positively or negatively, other cells involved in immune responses. T cells develop in the thymus from bone marrow-derived precursors. These precursors (thymocytes) proliferate, rearrange the genes encoding subunits of the T cell antigen receptor, which endow them with their unique antigen specificity, and undergo various degrees of pre-programming for their functions in immune responses. Thus, analyzing T cell development in the thymus is essential for understanding their functions in immune responses. In addition, the thymus constitutes an attractive experimental model to analyze mechanisms of cell proliferation, differentiation and survival, all of which are involved in thymocyte development. This chapter presents a quick overview of the key events characterizing intrathymic T cell development, as an introduction for readers entering this field of study.