Epidemiology and trends in neonatal early onset sepsis in California, 2010-2017
Epidemiology and trends in neonatal early onset sepsis in California, 2010-2017
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DOI：
10.1038/s41372-022-01393-7
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发表时间：
2022-04-25
影响因子：
2.9
通讯作者：
Frymoyer, Adam
中科院分区：
文献类型：
--
作者：
Joshi, Neha S.;Huynh, Karen;Frymoyer, Adam
目的探讨新生儿早发性败血症(EOS)的疾病负担模式，以指导EOS的管理。研究设计：回顾性队列研究。结果在加州围产期质量护理协作中心的136个NICU中，2010至2017年间出生的2872,964名新生儿中，共有1535例EOS病例。早产儿EOS发病率为7.4/1000(E.Coli：4.3，GBS：1.1)，早产晚期为0.76/1000(E.Coli：0.29，GBS：0.22)，足月儿为0.31/1000(E.Coli：0.07，GBS：0.13)。总体发病率没有显著变化，尽管注意到大肠埃希氏菌(P<；0.001)的发病率增加，GBS的发病率(P=0.04)下降。调整胎龄后，病原体致死的几率没有差异(p>；0.2)。结论2010-2017年间，加州NICU的EOS总体发病率保持稳定，但大肠埃希菌发病率有所上升，GBS EOS发病率有所下降。
Objective This study evaluated patterns of neonatal early onset sepsis (EOS) disease burden to guide approaches to EOS management. Study Design Retrospective cohort. Result A total of 1535 EOS cases were identified amongst 2,872,964 neonates born between 2010 and 2017 at 136 NICUs within the California Perinatal Quality Care Collaborative. EOS incidence was 7.4 per 1000 (E coli: 4.3, GBS: 1.1) in preterm, 0.76 per 1000 (E coli: 0.29, GBS: 0.22) in late preterm, and 0.31 per 1000 (E coli: 0.07, GBS 0.13) in term neonates. There was no significant change in overall incidence, though an increase in E coli (p < 0.001) and decrease in GBS (p = 0.04) incidence were noted. After adjusting for gestational age, there was no difference in the odds of death by pathogen (p > 0.2). Conclusion The overall EOS incidence remained steady in California NICUs from 2010-2017, though an increase in E coli and decrease in GBS EOS incidence was noted.