Access to N-Carbonyl Derivatives of Iminosydnones by Carbonylimidazolium Activation
Access to N-Carbonyl Derivatives of Iminosydnones by Carbonylimidazolium Activation
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DOI：
10.1021/acs.orglett.0c00600
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发表时间：
2020-03-20
期刊：
影响因子：
5.2
通讯作者：
Taran, Frederic
中科院分区：
文献类型：
--
作者：
Riomet, Margaux;Porte, Karine;Taran, Frederic
开发了一种亚氨基糖酮 N-环外官能化的新方法，包括在羰基咪唑鎓激活的亚氨基糖酮上添加多种亲核试剂。这种实用且高度通用的方法提供了新一类亚氨基糖酮的制备方法，并开辟了一条直接的合成路线来制备基于亚氨基糖酮的前药。
A new methodology for N-exocyclic functionalization of iminosydnones was developed involving the addition of a large variety of nucleophiles on carbonyl-imidazolium-activated iminosydnones. This practical and highly versatile method provided access to new classes of iminosydnones and opened a straightforward synthetic route to prepare iminosydnone-based prodrugs.