Tensin links energy metabolism to extracellular matrix assembly.
Tensin links energy metabolism to extracellular matrix assembly.
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DOI：
10.1083/jcb.201702025
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发表时间：
2017-04-03
期刊：
影响因子：
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通讯作者：
Norman JC
中科院分区：
文献类型：
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作者：
Dornier E;Norman JC
Dornier和Norman讨论了Georgiadou等人的发现，该发现表明AMPK活性调节张力蛋白表达，从而调节α5β1-整联蛋白和纤维粘附组装。整合素功能的调节是基本细胞过程的关键，包括细胞迁移和细胞外基质（ECM）组装。在这个问题上，Georgiadou et al.（2017. J. Cell Biol. https：//doi.org/10.1083/jcb.201609066）报道了代谢传感器腺苷一磷酸活化的蛋白激酶影响张力蛋白的产生以调节α5β1-整联蛋白和纤维粘附组装，从而揭示了能量代谢和ECM组装之间的重要联系。
Dornier and Norman discuss the findings by Georgiadou et al. that show that AMPK activity regulates tensin expression, thereby modulating α5β1-integrin and fibrillar adhesion assembly. The regulation of integrin function is key to fundamental cellular processes, including cell migration and extracellular matrix (ECM) assembly. In this issue, Georgiadou et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201609066) report that the metabolic sensor adenosine monophosphate–activated protein kinase influences tensin production to regulate α5β1-integrin and fibrillar adhesion assembly and thus reveal an important connection between energy metabolism and ECM assembly.