Quantification of L-type fatty acid binding protein in the urine of preterm neonates
Quantification of L-type fatty acid binding protein in the urine of preterm neonates
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DOI：
10.1016/j.earlhumdev.2005.03.012
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发表时间：
2005-07-01
影响因子：
2.5
通讯作者：
Mayumi, M
中科院分区：
文献类型：
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作者：
Tsukahara, H;Sugaya, T;Mayumi, M
我们测量了早产儿在出生后第1天、第5-10天和第25-30天的尿L型脂肪酸结合蛋白（LFABP）排泄量。早产儿尿L-FABP水平（以肌酐的比值表示）明显高于健康成人。在研究期间，它们没有显著变化。尿L-FABP水平与第1天尿N-乙酰-β-D-氨基葡萄糖苷酶活性呈显著正相关，与第25-30天尿8-羟基-2 '-脱氧鸟苷呈显著正相关。这些结果表明L-FABP在新生儿肾脏中表达。我们的研究结果也可能指出近端肾小管损伤和氧化应激对L-FABP尿排泄的潜在影响。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
We measured urinary excretion of L-type fatty acid binding protein (LFABP) in preterm neonates on days 1, 5-10, and 25-30 of life. Urinary L-FABP levels (expressed as the ratio to creatinine) in preterm neonates were considerably higher than those of healthy adults. They did not change significantly during the study period. Urinary L-FABP levels showed significant positive correlation with those of urinary N-acetyl-beta-D-glucosaminidase activity on day 1, and with those of 8-hydroxy-2'-deoxyguanosine on days 25-30. These results suggest that L-FABP is expressed in the neonatal kidney. Our results may also point to potential effects of proximal tubular damage and oxidative stress on urinary excretion of L-FABP. (c) 2005 Elsevier Ireland Ltd. All rights reserved.