A critical role for phagocytosis in resistance to malaria in iron-deficient mice
A critical role for phagocytosis in resistance to malaria in iron-deficient mice
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DOI：
10.1002/eji.201040942
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发表时间：
2011-05-01
影响因子：
5.4
通讯作者：
Hisaeda, Hajime
中科院分区：
文献类型：
--
作者：
Matsuzaki-Moriya, Chikako;Tu, Liping;Hisaeda, Hajime
缺铁性贫血（IDA）和疟疾仍然是发展中国家儿童的威胁。患有IDA的儿童对疟疾具有抵抗力，但其原因尚不清楚。在这项研究中，我们提出了保护IDA个人使用啮齿类疟疾寄生虫，约氏疟原虫（Py）对疟疾的潜在机制。我们表明，红细胞内的增殖和扩增的Py寄生虫不抑制IDA红细胞和免疫反应特异性Py寄生虫在IDA小鼠没有增强。我们还发现，寄生的IDA细胞更容易被吞噬细胞在体外比对照细胞，导致寄生细胞的快速清除和保护IDA小鼠免受疟疾被废除，通过抑制吞噬作用。这种快速清除的一个可能原因可能是在寄生的IDA红细胞的外小叶处磷脂酰丝氨酸的暴露增加。这项研究的结果表明，寄生IDA红细胞被吞噬细胞，这感觉寄生IDA红细胞的膜结构的变化消除。
Both iron-deficient anemia (IDA) and malaria remain a threat to children in developing countries. Children with IDA are resistant to malaria, but the reasons for this are unknown. In this study, we addressed the mechanisms underlying the protection against malaria observed in IDA individuals using a rodent malaria parasite, Plasmodium yoelii (Py). We showed that the intra-erythrocytic proliferation and amplification of Py parasites were not suppressed in IDA erythrocytes and immune responses specific for Py parasites were not enhanced in IDA mice. We also found that parasitized IDA cells were more susceptible to engulfment by phagocytes in vitro than control cells, resulting in rapid clearance of parasitized cells and that protection of IDA mice from malaria was abrogated by inhibiting phagocytosis. One possible reason for this rapid clearance might be increased exposure of phosphatidylserine at the outer leaflet of parasitized IDA erythrocytes. The results of this study suggest that parasitized IDA erythrocytes are eliminated by phagocytic cells, which sense alterations in the membrane structure of parasitized IDA erythrocytes.