Molecular comparison of echovirus 11 strains circulating in Europe during an epidemic of multisystem hemorrhagic disease of infants indicates that evolution generally occurs by recombination
Molecular comparison of echovirus 11 strains circulating in Europe during an epidemic of multisystem hemorrhagic disease of infants indicates that evolution generally occurs by recombination
复制标题
DOI：
10.1016/j.virol.2004.04.026
复制
发表时间：
2004-07-20
期刊：
影响因子：
3.7
通讯作者：
Delpeyroux, F
中科院分区：
文献类型：
--
作者：
Chevaliez, S;Szendröi, A;Delpeyroux, F
我们比较了1989年在匈牙利严重流行的埃可病毒11（E11）株与原型E11株格雷格雷和其他E11株，其中大多数是在同一时期在欧洲（芬兰，荷兰，罗马尼亚，俄罗斯）从散发病例或环境水中分离出来的。部分测序表明，匈牙利菌株相互之间以及与大多数欧洲菌株密切相关。他们特别密切相关的一个罗马尼亚菌株与零星的偏瘫病例和几个芬兰菌株从环境中分离的水。对一个匈牙利株、罗马尼亚株和一个芬兰株的全基因组进行测序，发现在基因组的5'端只有几个核苷酸的差异，包括5'端非翻译区（5 '-NTR）和衣壳编码区。然而，在基因组的3'半（非结构病毒蛋白区和3'-NTR）的核苷酸序列中观察到显著差异，表明这些毒株是最近通过与其他未知的E11或肠道病毒株的遗传重组而独立进化的。(C)2004爱思唯尔公司All rights reserved.
We compared echovirus 11 (E11) strains implicated in a severe epidemic in Hungary in 1989 with the prototype E11 strain Gregray and with other E11 strains, most of which were isolated over the same period in Europe (Finland, The Netherlands, Romania, Russia) from sporadic cases or from environmental water. Partial sequencing indicated that the Hungarian strains were closely related to each other and to most European strains. They were particularly closely related to one Romanian strain associated with a sporadic case of hemiparesis and several Finnish strains isolated from environmental water. Sequencing of the complete genomes of one Hungarian strain, the Romanian strain, and one Finnish strain revealed differences of only a few nucleotides in the 5' half of the genome, including the 5' nontranslated region (5'-NTR) and the capsid coding region. However, significant differences were observed in the nucleotide sequences of the 3' half of the genome (nonstructural viral protein region and 3'-NTR), indicating that these strains evolved recently and independently by genetic recombination with other unknown E11 or enterovirus strains. (C) 2004 Elsevier Inc. All rights reserved.