Three new furan derivatives and a new fatty acid from a Taiwanese marine sponge Plakortis simplex
Three new furan derivatives and a new fatty acid from a Taiwanese marine sponge Plakortis simplex
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DOI：
10.1021/np000413d
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发表时间：
2001-03-01
影响因子：
5.1
通讯作者：
Kuo, YH
中科院分区：
文献类型：
--
作者：
Shen, YC;Prakash, CVS;Kuo, YH
从台湾海绵Plakortis simplex中分离出三种新的呋喃衍生物plakorsins a -c（6-8）和一种新的脂肪酸plakortic acid(9)，此外还有已知的代谢产物chondrillin(1)、6-epi-chondrillin(2)、2-氧-2,5-二氢呋喃-5-乙酸甲酯（甲基1,4-环氧-1-氧-2-己烯酸酯）(3)、二甲基-酮己二酸酯(4)和顺式、顺式mucconic酸单甲基酯(5)。这些化合物的结构主要根据光谱数据和化学方法确定。生物学研究表明化合物7对COLO-250和KB-16细胞具有细胞毒活性，化合物1对KB-16细胞具有细胞毒活性。
Three new furan derivatives, plakorsins A-C (6-8), together with a new fatty acid, plakortic acid (9), have been isolated from the Taiwanese marine sponge Plakortis simplex in addition to the known metabolites chondrillin (1), 6-epi-chondrillin (2), 2-oxo-2,5-dihydrofuran-5-acetic acid methyl ester (methyl 1,4-epoxy-1-oxo-2-hexenoate) (3), dimethyl beta -ketoadipate (4), and the monomethyl ester of cis,cis-muconic acid (5). The structures of these compounds were established mainly on the basis of spectral data and chemical methods. Biological studies revealed that compound 7 exhibited cytotoxic activity against COLO-250 and KB-16 cells, and compound 1 is active against KB-16 cells.