The Role of Myeloid Cells in Acute Kidney Injury and Kidney Repair.
The Role of Myeloid Cells in Acute Kidney Injury and Kidney Repair.
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DOI：
10.34067/kid.0000672021
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发表时间：
2021-09
期刊：
影响因子：
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通讯作者：
Leyuan Xu
中科院分区：
文献类型：
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作者：
Leyuan Xu
AKI仍然非常普遍，但没有最佳的治疗方法来预防它或促进最初损伤后的恢复。实验研究表明，先天性和适应性免疫反应在AKI中起核心作用。在对损伤的反应中，骨髓细胞首先根据来自受损微环境的特定信号被招募和激活。随后免疫细胞的募集和激活状态取决于损伤和恢复的阶段，反映了免疫表型的动态和多样性。在这篇综述中，我们强调了我们目前对髓细胞参与AKI后损伤、修复和纤维化机制的理解。
AKI remains highly prevalent, yet no optimal therapy is available to prevent it or promote recovery after initial insult. Experimental studies have demonstrated that both innate and adaptive immune responses play a central role during AKI. In response to injury, myeloid cells are first recruited and activated on the basis of specific signals from the damaged microenvironment. The subsequent recruitment and activation state of the immune cells depends on the stage of injury and recovery, reflecting a dynamic and diverse spectrum of immunophenotypes. In this review, we highlight our current understanding of the mechanisms by which myeloid cells contribute to injury, repair, and fibrosis after AKI.