Modeling of spreading cortical depression using a realistic head model.
Modeling of spreading cortical depression using a realistic head model.
复制标题
使用逼真的头部模型对扩散的皮质抑郁进行建模。
DOI：
10.1023/a:1022200401741
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Tepley,N
中科院分区：
文献类型：
--
作者：
Wijesinghe,RS;Roth,BJ;Tepley,N
Barkley and colleagues in 1990 reported large amplitude waves (LAWs) in time series magnetoencephalography (MEG) recordings from migraine patients and inferred that these LAWs arose from spreading cortical depression (SCD). SCD propagates slowly across the cortex in all species in which it has been observed. Previously, we reported that LAWs could be simulated and compared with the recorded signals using the four-sphere model (Wijesinghe and Tepley 1997). We showed that LAWs could arise from the propagation of SCD across a sulcus. In this paper, we model LAWs using a realistically shaped head model based on magnetic resonance images (MRI) (Roth et al. 1993). Simulated signals using this model are similar to the recorded signals. In this model, current dipoles represent the excitable neurons in the cortex and magnetic fields created by these individual dipoles are calculated. The magnetic field arising from the excited area of cortex is obtained by summing the fields due to these individual dipoles.
