A fully resolved multiphysics model of gastric peristalsis and bolus emptying in the upper gastrointestinal tract.
A fully resolved multiphysics model of gastric peristalsis and bolus emptying in the upper gastrointestinal tract.
复制标题
DOI：
10.1016/j.compbiomed.2021.104948
复制
发表时间：
2022-04
影响因子：
7.7
通讯作者：
中科院分区：
文献类型：
--
作者：
在过去的几十年里，器官系统的计算机建模极大地促进了我们对其生理和生物力学功能的理解。尽管消化系统在人体正常功能中相对重要，但目前缺乏用于上消化道（包括食道和胃）的高保真模型。在这项工作中，我们提出了一个详细的上胃肠道数值模型，该模型不仅考虑了肌肉壁的纤维结构，而且还考虑了它们在正常消化功能期间帮助运输的多相成分。具有代表性的胃几何形状三维模型的构建细节，以及为每层分配圆形和纵向肌纤维方向的简单策略。我们开发了一个全分辨率的胃模型，通过系统地激活嵌入胃中的肌肉纤维来模拟胃蠕动。在此之后，我们第一次模拟了重力驱动的小丸排入胃中，这是由于胃中摄入的内容物和液体内容物之间的密度差异。最后，我们提出一个病例的逆行流动的液体从胃到食道，类似的现象酸反流。这个详细的上胃肠道计算模型为未来的模型研究胃酸反流的生物力学和探讨胃旁路手术的各种策略提供了基础，以解决日益严重的肥胖问题。
Over the past few decades, in silico modeling of organ systems has significantly furthered our understanding of their physiology and biomechanical function. In spite of the relative importance of the digestive system in normal functioning of the human body, there is a scarcity of high-fidelity models for the upper gastrointestinal tract including the esophagus and the stomach. In this work, we present a detailed numerical model of the upper gastrointestinal tract that not only accounts for the fiber architecture of the muscle walls, but also the multiphasic components they help transport during normal digestive function. Construction details for 3D models of representative stomach geometry are presented along with a simple strategy for assigning circular and longitudinal muscle fiber orientations for each layer. We developed a fully resolved model of the stomach to simulate gastric peristalsis by systematically activating muscle fibers embedded in the stomach. Following this, for the first time, we simulate gravity-driven bolus emptying into the stomach due to density differences between ingested contents and fluid contents of the stomach. Finally, we present a case of retrograde flow of fluid from the stomach into the esophagus, resembling the phenomenon of acid reflux. This detailed computational model of the upper gastrointestinal tract provides a foundation for future models to investigate the biomechanics of acid reflux and probe various strategies for gastric bypass surgeries to address the growing problem of obesity.
登录
查看更多内容
影响因子：
3.8
作者：
Bayer, J. D.;Blake, R. C.;Plank, G.;Trayanova, N. A.
通讯作者：
Trayanova, N. A.
影响因子：
4.1
作者：
Bao, Yuanxun;Donev, Aleksandar;Peskin, Charles S.
通讯作者：
Peskin, Charles S.
DOI：
10.1002/cnm.2888
发表时间：
2017-12
影响因子：
2.1
作者：
Griffith BE;Luo X
通讯作者：
Luo X
DOI：
10.1152/ajpgi.00350.2012
发表时间：
2013-03-01
影响因子：
4.5
作者：
Imai, Yohsuke;Kobayashi, Ikuma;Yamaguchi, Takami
通讯作者：
Yamaguchi, Takami
DOI：
10.1016/j.cma.2007.09.015
发表时间：
2008-01-01
影响因子：
7.2
作者：
Boffi, Daniele;Gastaldi, Lucia;Peskin, Charles S.
通讯作者：
Peskin, Charles S.