Mechanobiological stability of biological soft tissues
Mechanobiological stability of biological soft tissues
复制标题
DOI：
10.1016/j.jmps.2018.12.013
复制
发表时间：
2019-04-01
影响因子：
5.3
通讯作者：
Humphrey, Jay D.
中科院分区：
文献类型：
--
作者：
Latorre, Marcos;Humphrey, Jay D.
与所有其他材料一样，生物软组织也遵循一般物理定律，包括控制机械平衡和稳定性的物理定律。然而，此外，这些组织能够对其机械和化学环境的变化做出积极的反应。因此，迫切需要从理论上理解这些过程。在本文中，我们提出了一种新的基于速率的约束混合物配方，适用于研究暴露于材料成分或施加载荷的瞬时或持续变化的软组织的机械生物学平衡和稳定性。这些概念针对动脉力学中的典型问题进行了说明，区分了可能的稳定与不稳定的机械生物学反应。此类分析有望深入了解控制健康和疾病进展的生物过程。 (C) 2018 Elsevier Ltd. 保留所有权利。
Like all other materials, biological soft tissues are subject to general laws of physics, including those governing mechanical equilibrium and stability. In addition, however, these tissues are able to respond actively to changes in their mechanical and chemical environment. There is, therefore, a pressing need to understand such processes theoretically. In this paper, we present a new rate-based constrained mixture formulation suitable for studying mechanobiological equilibrium and stability of soft tissues exposed to transient or sustained changes in material composition or applied loading. These concepts are illustrated for canonical problems in arterial mechanics, which distinguish possible stable versus unstable mechanobiological responses. Such analyses promise to yield insight into biological processes that govern both health and disease progression. (C) 2018 Elsevier Ltd. All rights reserved.