Mechanism of toxicity of esters of caffeic and dihydrocaffeic acids
Mechanism of toxicity of esters of caffeic and dihydrocaffeic acids
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DOI：
10.1016/s0968-0896(00)00238-8
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发表时间：
2001-01-01
影响因子：
3.5
通讯作者：
Selassie, CD
中科院分区：
文献类型：
--
作者：
Etzenhouser, B;Hansch, C;Selassie, CD
最近合成了咖啡酸和二氢咖啡酸的各十种酯。这些酯与L1210白血病和MCF-7乳腺癌细胞在培养中的细胞毒性评价，导致了基本上不同的QSAR的每个系列的描绘。二氢咖啡酸酯的L1210 QSAR类似于简单酚和雌激素酚的QSAR。然而，有关咖啡酸酯的QSAR与其姐妹的QSAR有很大不同。这种差异可能归因于侧链中存在烯键。咖啡酸辛酯对白血病细胞的毒性几乎是广泛研究的苯乙酯（CAFE）的十倍。(C)2000爱思唯尔科技有限公司版权所有。
Ten esters each of caffeic acid and dihydrocaffeic acid have recently been synthesized. Cytotoxicity evaluations of these esters versus L1210 leukemia and MCF-7 breast cancer cells in culture have led to the delineation of substantially different QSAR for each series. The L1210 QSAR for dihydrocaffeic acid esters resembles the QSAR obtained for simple phenols and estrogenic phenols. However, the QSAR pertaining to the caffeic acid esters differs considerably from its sister QSAR. This difference may be attributed to the presence of the olefinic linkage in the side chain. The octyl ester of caffeic acid is nearly ten times as toxic to the leukemia cells than the widely studied phenethyl ester, CAFE. (C) 2000 Elsevier Science Ltd. All rights reserved.