Development of a test to measure gastric accommodation in humans
Development of a test to measure gastric accommodation in humans
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DOI：
10.1152/ajpgi.1999.277.6.g1217
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发表时间：
1999-12-01
影响因子：
4.5
通讯作者：
O'Connor, MK
中科院分区：
文献类型：
--
作者：
Kuiken, SD;Samsom, M;O'Connor, MK
餐后腹胀、膨胀、早饱和恶心症状与餐后胃调节受损相关，这可通过近端胃中的胃内、气压控制球囊和远端胃中的超声检测。我们的目的是发展一种非侵入性的方法来测量整个胃调节反射。在10名健康志愿者中，我们使用单光子发射计算机断层扫描（SPECT）测量空腹和餐后胃容积。该方法包括静脉注射Tc-99 m高锝酸盐和用Analyze软件重建胃断层图像。SPECT-Analyze成像检测在体餐后胃调节反射。平均空腹胃容量为182 ± 11（SE）ml，平均餐后胃容量为690 ± 32 ml（P < 0.001）。胃的近端和远端节段在餐后体积上都显示出2 - 4倍的差异。空腹和餐后容量估计值的观察者内变异系数分别为9%和8%;观察者间变异分别为13%和12%。SPECT-分析非侵入性测量人类餐后胃（总，近端和远端）调节。这种方法似乎有希望比较的调节反应在健康和疾病，并进行调节反应的机制研究。
Postprandial symptoms of bloating, distension, early satiety, and nausea are associated with impaired postprandial gastric accommodation, which is detectable by means of an intragastric, barostatically controlled balloon in the proximal stomach and by ultrasound in the distal stomach. Our aim was to develop a noninvasive method to measure the entire gastric accommodation reflex. In 10 healthy volunteers, we used single photon emission computed tomography (SPECT) to measure fasting and postprandial gastric volumes. This method involved intravenous injection of Tc-99m pertechnetate and gastric reconstruction of tomographic images with Analyze software. SPECT-Analyze imaging detects the postprandial gastric accommodation reflex in vivo. Mean fasting gastric volume was 182 +/- 11 (SE) ml and mean postprandial volume was 690 +/- 32 mi (P < 0.001). Both proximal and distal segments of stomach showed a two- to almost fourfold difference in volumes postprandially. Intraobserver coefficients of variation in estimated fasting and postprandial volumes were 9 and 8%; interobserver variations were 13 and 12%, respectively. SPECT-Analyze noninvasively measures postprandial gastric (total, proximal, and distal) accommodation in humans. This method appears promising to compare the accommodation response in health and disease and to perform mechanistic studies of the accommodation response.