PHYSIOLOGICAL EVIDENCE FOR 2 DISTINCT GABA(A) RESPONSES IN RAT HIPPOCAMPUS
PHYSIOLOGICAL EVIDENCE FOR 2 DISTINCT GABA(A) RESPONSES IN RAT HIPPOCAMPUS
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DOI：
10.1016/0896-6273(93)90310-n
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发表时间：
1993-02-01
期刊：
影响因子：
16.2
通讯作者：
PEARCE, RA
中科院分区：
文献类型：
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作者：
PEARCE, RA
γ-氨基丁酸（GABA（A））受体是参与突触抑制的配体门控离子载体。生物化学和分子生物学研究表明，存在相当大的受体异质性，但在大脑中尚未确定抑制性GABA（A）突触反应之间的生理差异。本报告描述了两个解剖学分离的GABA（A）介导的突触电流在海马CA 1区，具有不同的生理，药理学和功能特性。GABA（A，快速）进入细胞体或其附近，迅速衰减（3-8 ms），被呋塞米阻断，并迅速减少兴奋性反应。GABA（A，慢）远离细胞体进入，缓慢衰减（30-70 ms），不被呋塞米阻断，并成为常规公认的早期抑制性突触后电位的基础。产生这些反应的受体可能代表GABA（A）受体的亚型。
The gamma-aminobutyric acid(A) (GABA(A)) receptor is a ligand-gated ionophore involved in synaptic inhibition. Biochemical and molecular biological studies indicate that considerable receptor heterogeneity exists, but physiological differences between inhibitory GABA(A) synaptic responses have not been identified in the brain. The present report describes two anatomically segregated GABA(A)-mediated synaptic currents in the hippocampal CA1 region that have distinct physiological, pharmacological, and functional properties. GABA(A,fast) enters at or near the cell body, decays rapidly (3-8 ms), is blocked by furosemide, and rapidly curtails the excitatory response. GABA(A,slow) enters far from the cell body, decays slowly (30-70 ms), is not blocked by furosemide, and underlies the conventionally recognized early inhibitory postsynaptic potential. The receptors producing these responses may represent subtypes of the GABA(A) receptor.