Synthesis of Naphthalimine-derived Dye and Its Applications in Fluorescent Imaging and Dyeing Surgical Suture Materials
Synthesis of Naphthalimine-derived Dye and Its Applications in Fluorescent Imaging and Dyeing Surgical Suture Materials
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萘亚胺染料的合成及其在荧光成像和手术缝合材料染色中的应用
DOI：
10.1002/slct.201800342
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发表时间：
2018
期刊：
影响因子：
2.1
通讯作者：
Zheng Laijiu
中科院分区：
文献类型：
--
作者：
Xiong Xiaoqing;Zhi Weiru;Yan Jun;Song Wenjing;Du Hui;Zhao Hongjuan;Li Feixia;Song Fengling;Sun Yanfeng;Zheng Laijiu
本研究设计并合成了基于双光子萘亚胺的NP-吲哚美辛。NP-吲哚美辛具有较高的荧光量子效率（在DMSO中为0.98）、较大的Stokes位移（>77 nm）和可行的双光子作用截面NP-吲哚美辛用于活细胞的荧光成像，NP‐吲哚美辛用于染色可吸收胶原外科缝线，构建荧光外科缝线。单光子和双光子荧光成像发现NP-吲哚美辛在缝线内外均匀分布。因此，NP ‐吲哚美辛的直接合成及其成分的广泛可用性意味着它既可以用于观察伤口愈合，也可以作为体内使用的荧光警告材料。
In this study,NP‐indometacin, which was based on the two‐photon naphthalimine, was designed and synthesized. The anti‐inflammatory material indometacin was introduced intoNP‐indometacinso that the toxicity of this fluorescent dye was reduced when applied to living organisms.NP‐indometacinhad high fluorescence quantum efficiency (0.98 in DMSO), a large Stokes shift (>77 nm) and feasible two‐photon action cross section (45 GM in DMSO).NP‐indometacinwas utilized for the fluorescence imaging of living cells, and the high cell viability rate (>80%) indicated that this material had low toxicity in living organisms.NP‐indometacinwas used to dye absorbable collagen surgical suture and constructed fluorescent surgical suture. It was found by one‐ and two‐photon fluorescence imaging thatNP‐indometacindistributed uniformly both outside and inside the sutures. Therefore, the straightforward synthesis ofNP‐indometacinand the wide availability of its constituents mean that it could both be highly useful for the observation of the healing of wounds and as a fluorescent warning material that is usedin vivo.