Gallium(III)- and Thallium(III)-Encapsulated Polyoxopalladates: Synthesis, Structure, Multinuclear NMR, and Biological Activity Studies.
Gallium(III)- and Thallium(III)-Encapsulated Polyoxopalladates: Synthesis, Structure, Multinuclear NMR, and Biological Activity Studies.
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DOI：
10.1021/acs.inorgchem.3c01530
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发表时间：
2023-08
影响因子：
4.6
通讯作者：
Tiancong Ma;Xiang Ma;Zhengguo Lin;Jiayao Zhang;Peng Yang;Tibor Csupász;I. Tóth;S. Misirlić-Denčić;A. Isakovic;D. Lembo;M. Donalisio;U. Kortz
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文献类型：
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作者：
Tiancong Ma;Xiang Ma;Zhengguo Lin;Jiayao Zhang;Peng Yang;Tibor Csupász;I. Tóth;S. Misirlić-Denčić;A. Isakovic;D. Lembo;M. Donalisio;U. Kortz
合成了三种含镓(III)和铊(III)的多氧钯酸盐(POP)，并在固相和溶液中对它们进行了结构表征，即：磷酸盐封端的12-Pal酸纳米立方体[XPd12O8(PO4)8]13-(X=GaIII，GaPd12P8；X=TlIII，TlPd12P8)和23-Pal酸双立方体[Tl2IIIPd23P14O70(OH)2]20-(Tl2Pd23P14)。长方体POP，GaPd12P8和TlPd12P8是溶液稳定的，分别由31P，71Ga和205Tl核磁共振(NMR)谱证实。最令人感兴趣的是，自旋-自旋耦合方案允许通过31P和205Tl核磁共振组合对含TlIII的持久性有机污染物的溶液行为进行深入研究，包括Tl2Pd23P14主要碎片的化学计量。此外，生物学研究还证实了GaPd12P8和TlPd12P8的抗肿瘤和抗病毒活性，它们被证实与顺铂一样有效地抑制人黑色素瘤和急性早幼粒细胞白血病细胞。此外，GaPd12P8和TlPd12P8对HSV-2和HCMV两种疱疹病毒均有抑制作用，且呈剂量-反应关系。
Three gallium(III)- and thallium(III)-containing polyoxopalladates (POPs) have been synthesized and structurally characterized in the solid state and in solution, namely, the phosphate-capped 12-palladate nanocubes [XPd12O8(PO4)8]13- (X = GaIII, GaPd12P8; X = TlIII, TlPd12P8) and the 23-palladate double-cube [Tl2IIIPd23P14O70(OH)2]20- (Tl2Pd23P14). The cuboid POPs, GaPd12P8 and TlPd12P8, are solution stable as verified by the respective 31P, 71Ga, and 205Tl nuclear magnetic resonance (NMR) spectra. Of prime interest, the spin-spin coupling schemes allowed for an intimate study of the solution behavior of the TlIII-containing POPs via a combination of 31P and 205Tl NMR, including the stoichiometry of the major fragments of Tl2Pd23P14. Moreover, biological studies demonstrated the antitumor and antiviral activity of GaPd12P8 and TlPd12P8, which were validated to be as efficient as cis-platinum against human melanoma and acute promyelocytic leukemia cells. Furthermore, GaPd12P8 and TlPd12P8 exerted inhibitory activity against two herpetic viruses, HSV-2 and HCMV, in a dose-response manner.