Enantioselective liquid-liquid extraction of DL-mandelic acid using chiral diphosphine ligands as extractants
Enantioselective liquid-liquid extraction of DL-mandelic acid using chiral diphosphine ligands as extractants
复制标题
使用手性二膦配体作为萃取剂对DL-扁桃酸进行对映选择性液-液萃取
DOI：
10.1002/chir.23054
复制
发表时间：
2019-03-01
期刊：
影响因子：
2
通讯作者：
Cao, Ting
中科院分区：
文献类型：
--
作者：
Ma, Yu;Liu, Xiong;Cao, Ting
为了拓展手性双膦配体的应用范围，分别以（S）-BINAP、（S）-SEGPHOS和（S）-MeO-BIPHEP为萃取剂，对DL-扁桃酸进行了识别。结果表明，（S）-SEGPOS-Cu对DL-扁桃酸具有较强的识别能力，操作对映选择性（α）为2.677。系统研究了以（S）-SEGPOS-Cu为萃取剂萃取DL-扁桃酸的工艺。采用性能因子（pf）综合评价萃取效果。通过响应面法（RSM）优化，确定了最佳提取条件为温度5.5 ℃、（S）-SEGPOS-Cu浓度3.0 mmol/L、pH 8.0。pf的预测值和实验最大值分别为0.26374和0.26839。
In order to expand the application range of chiral diphosphine ligands, (S)-BINAP, (S)-SEGPHOS, and (S)-MeO-BIPHEP were employed as extractants to recognize DL-mandelic acid. The results indicated that (S)-SEGPHOS-Cu exhibited considerable ability to recognize DL-mandelic acid with operational enantioselectivity (alpha) of 2.677. The process of extraction of DL-mandelic acid using (S)-SEGPHOS-Cu as extractant was systematically investigated. Performance factor (pf) was adopted to comprehensively evaluate the extraction. After optimization by response surface methodology (RSM), the optimal extraction condition is temperature of 5.5 degrees C, (S)-SEGPHOS-Cu concentration of 3.0 mmol/L, and pH of 8.0. And the predicted and experimental maximum values of pf were 0.26374 and 0.26839, respectively.