ON NATURE OF CUTANEOUS SENSORY MECHANISMS
ON NATURE OF CUTANEOUS SENSORY MECHANISMS
复制标题
DOI：
10.1093/brain/85.2.331
复制
发表时间：
1962-01-01
期刊：
影响因子：
14.5
通讯作者：
WALL, PD
中科院分区：
文献类型：
--
作者：
MELZACK, R;WALL, PD
某些感觉的问题，也许比神经学的任何其他方面都更容易引起激烈的争论。特别是，关于冯·弗雷（1895）的四种皮肤形态理论的观点已经从一个极端转向另一个极端（见Dallenbach，1927，1939）。在过去的十年里，威德尔及其同事的牛津小组对该理论的全盘否定，以及后来新出版的《生理学手册》的作者们对该理论有效性的重申，都证明了这一点。Rose and Mountcastle（1960），pp. 390-391）写道：”牛津小组的工作人员似乎完全否认存在的方式具体受体.而我们倾向于认为，与冯弗雷一样，原则上（触摸）感觉可以出现，如果一个单独的适当的外围纤维被激活。同样，斯威特（Sweet，1959，p.460）主张”疼痛是一种具有自身中枢和外周器官的感觉”，佐特曼（Zotterman，1959 a，p.431）在本章的主旨中引用了布利克斯的话：“冷和热的不同感觉是由皮肤中不同的特定终末器官的刺激产生的。“我们在这里的意图是审查有争议的问题，并试图根据最近的证据解决其中一些问题。既然我们正在步入一个早已被人熟知的特异性理论的迷宫，那么我们就必须在一开始就明确我们同意和不同意早期作者的观点。关于某些感觉，目前有两种对立的观点：（1）特定情态理论，
THE problem of somesthesis, perhaps more than any other aspect of neurology, has led persistently to heated controversy. In particular, opinion regarding von Frey* s (1895) theory of four cutaneous modalities has swung from one extreme to the other (see Dallenbach, 1927, 1939). This has been exemplified during the past decade by the total repudiation of the theory by the Oxford group of Weddell and his colleagues, and the subsequent reaffirmation of its validity by writers in the new Handbook of Physiology. Thus, Rose and Mountcastle (1960, pp. 390-391) write that" the Oxford group of workers seems to deny altogether the existence of modality specific receptors... while we are inclined to think, with von Frey, that in principle (touch) sensation could arise if a single appropriate peripheral fiber were activated." Similarly, Sweet (1959, p. 460) argues for" Pain as a sensation with its own central and peripheral apparatus," and Zotterman (1959a, p. 431) keynotes his chapter by citing Blix:" The different sensations of cold and warm are produced by stimulation of separate specific end-organs in the skin." Our intention here is to examine the controversial issues and to attempt to resolve some of them in the light of recent evidence. Since we are stepping into the well-trodden maze of specificity theory, it is essential that we make explicit at the outset where we agree and disagree with earlier writers. There are currently two opposing schools of thought concerning somesthesis:(1) the specific modality theory of